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Rabbit polyclonal KCNS3 antibody (A7906)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal KCNS3 antibody.
Check alternative names for the antibodyExpand
Delayed rectifier K(+) channel alpha subunit 3 antibody|Voltage gated potassium channel subunit Kv9.3 antibody|Voltage-gated potassium channel subunit Kv9.3 antibody|Anti-KCNS3 antibody (ab26164)
SCBT cat No: sc-365497|sc-365979|
Rabbit polyclonal KCNS3 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human KCNS3
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 56kDa/Observed: Refer to figures
KCNS3 antibody was tube-contained.
KCNS3 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 . Heterotetrameric channel activity formed with KCNB1 show increased current amplitude with the threshold for action potential activation shifted towards more negative values in hypoxic-treated pulmonary artery smooth muscle cells (By similarity).
|Protein tissue specificity|| |
Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) . Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung .
|Protein sequence and domain|| |
The transmembrane segment S4 functions as voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Channel opening and closing is effected by a conformation change that affects the position and orientation of the voltage-sensor paddle formed by S3 and S4 within the membrane. A transmembrane electric field that is positive inside would push the positively charged S4 segment outwards, thereby opening the pore, while a field that is negative inside would pull the S4 segment inwards and close the pore. Changes in the position and orientation of S4 are then transmitted to the activation gate formed by the inner helix bundle via the S4-S5 linker region.Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.3/KCNS3 sub-subfamily.
|Protein cellular localization|| |
Cell membrane ; Multi-pass membrane protein . Note: May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 .
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
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|Product type|| |
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