Rabbit polyclonal KDM4A antibody (A7953)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KDM4A antibody (A7953)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KDM4A antibody.

Alternative names:

Check alternative names for the antibody

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JMJD2 antibody, JHDM3A antibody, JMJD2A antibody, TDRD14A antibody
JHDM3A antibody|JmjC domain containing histone demethylation protein 3A antibody|JmjC domain-containing histone demethylation protein 3A antibody|JMJD2 antibody|JMJD2A antibody|jumonji C domain containing histone demethylase 3A antibody|Jumonji domain containing 2 antibody|Jumonji domain containing 2A antibody|Jumonji domain containing protein 2A antibody|Jumonji domain-containing protein 2A antibody|KDM4A antibody|KDM4A_HUMAN antibody|KIAA0677 antibody|Lysine (K) specific demethylase 4A antibody|Lysine-specific demethylase 4A antibody|TDRD14A antibody|Tudor domain containing 14A antibody|Anti-KDM4A / JHDM3A / JMJD2A antibody – ChIP Grade (ab24545)

SCBT cat No: sc-81302|sc-271210|sc-135065|sc-373850|sc-54624|

Name

Rabbit polyclonal KDM4A antibody

Catalogue No.

A7953

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KDM4A

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 121kDa/Observed: Refer to figures

Formulation

KDM4A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KDM4A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JMJD2 antibody, JHDM3A antibody, JMJD2A antibody, TDRD14A antibody

Database links

Human UniProt/Swiss-Prot:O75164

Protein names

JMJD2, JHDM3A, JMJD2A, TDRD14A

Protein function

Histone demethylase that specifically demethylates ‘Lys-9’ and ‘Lys-36’ residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ‘Lys-4’, H3 ‘Lys-27’ nor H4 ‘Lys-20’. Demethylates trimethylated H3 ‘Lys-9’ and H3 ‘Lys-36’ residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.; Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The 2 Tudor domains recognize and bind methylated histone H3 ‘Lys-4’ residue (H3K4me). Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. Trimethylated H3 ‘Lys-4’ (H3K4me3) is bound in a cage of 3 aromatic residues, 2 of which are from the Tudor domain 2, while the binding specificity is determined by side-chain interactions involving residues from the Tudor domain 1. The Tudor domains are also able to bind trimethylated histone H3 ‘Lys-9’ (H3K9me3), di- and trimethylated H4 ‘Lys-20’ (H4K20me2 and H4K20me3). Has high affinity for H4K20me2, blocking recruitment of proteins such as TP53BP1.Belongs to the JHDM3 histone demethylase family.; Contains 1 C2HC pre-PHD-type zinc finger.; Contains 1 JmjC domain.; Contains 1 JmjN domain.; Contains 2 PHD-type zinc fingers.; Contains 2 Tudor domains.

Protein post-translational modifications

Ubiquitinated by RNF8 and RNF168 following DNA damage, leading to its degradation. Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited.

Protein cellular localization

Nucleus .

Background

This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.

Research area

All research areas>Transcription Regulators>JMJD
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize KDM4A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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