Rabbit polyclonal KDM7A antibody (A8266)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KDM7A antibody (A8266)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KDM7A antibody.

Alternative names:

Check alternative names for the antibody

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JHDM1D antibody
JHDM1D antibody|jmjc containing protein antibody|JmjC domain-containing histone demethylation protein 1D antibody|jumonji containing protein antibody|KDM7_HUMAN antibody|kiaa1718 antibody|Lysine-specific demethylase 7 antibody|Anti-JHDM1D antibody (ab37905)

SCBT cat No: sc-135489|sc-135490|

Name

Rabbit polyclonal KDM7A antibody

Catalogue No.

A8266

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KDM7A

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 107kDa/Observed: Refer to figures

Formulation

KDM7A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KDM7A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JHDM1D antibody

Database links

Human UniProt/Swiss-Prot:Q6ZMT4

Protein names

JHDM1D

Protein function

Histone demethylase required for brain development. Specifically demethylates dimethylated ‘Lys-9’ and ‘Lys-27’ (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 ‘Lys-20’ residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated ‘Lys-4’ of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.

Protein sequence and domain

The PHD-type zinc finger mediates the binding to H3K4me3. Binding to H3K4me3 prevents its access to H3K9me2.; The linker region is a critical determinant of demethylase specificity. It prevents the active site of JmjC to reach the target H3K9me2 when the PHD-type zinc finger binds to H3K4me3, while it favors selectivity toward H3K27me2.Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.; Contains 1 JmjC domain.; Contains 1 PHD-type zinc finger.

Protein cellular localization

Nucleus.

Note

AntibodyPlus can customize KDM7A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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