Rabbit polyclonal KHDRBS1 antibody (A6101)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KHDRBS1 antibody (A6101)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KHDRBS1 antibody.

Alternative names:

Check alternative names for the antibody

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p62 antibody, p68 antibody, Sam68 antibody
FLJ34027 antibody|GAP associated tyrosine phosphoprotein p62 antibody|GAP-associated tyrosine phosphoprotein p62 antibody|KH domain containing RNA binding signal transduction associated 1 antibody|KH domain-containing antibody|KHDR1_HUMAN antibody|Khdrbs1 antibody|p21 Ras GTPase activating protein associated p62 antibody|p21 Ras GTPase-activating protein-associated p62 antibody|p62 antibody|p68 antibody|RNA-binding antibody|Sam68 antibody|signal transduction-associated protein 1 antibody|Src associated in mitosis 68 kDa protein antibody|Src-associated in mitosis 68 kDa protein antibody|Anti-SAM68 antibody (ab26803)

SCBT cat No: sc-514404|

Name

Rabbit polyclonal KHDRBS1 antibody

Catalogue No.

A6101

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human KHDRBS1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to Figures

Formulation

KHDRBS1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KHDRBS1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

p62 antibody, p68 antibody, Sam68 antibody

Database links

Human UniProt/Swiss-Prot:Q07666

Protein names

p62, p68, Sam68

Protein function

Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to . RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5′-[AU]UAA-3′ as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway-dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 . Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity).; Isoform 3, which is expressed in growth-arrested cells only, inhibits S phase.

Protein tissue specificity

Ubiquitously expressed in all tissue examined. Isoform 1 is expressed at lower levels in brain, skeletal muscle, and liver whereas isoform 3 is intensified in skeletal muscle and in liver.

Protein sequence and domain

The KH domain is required for binding to RNA.; The Pro-rich domains are flanked by Arg/Gly-rich motifs which can be asymmetric dimethylated on arginine residues to give the DMA/Gly-rich regions. Selective methylation on these motifs can modulate protein-protein interactions (By similarity).Belongs to the KHDRBS family.; Contains 1 KH domain.

Protein post-translational modifications

Tyrosine phosphorylated by several non-receptor tyrosine kinases, LCK, FYN and JAK3. Negatively correlates with ability to bind RNA but required for many interactions with proteins. Phosphorylation by PTK6 negatively regulates its RNA binding ability. Phosphorylation by PTK6 at Tyr-440 dictates the nulear localization of KHDRBS1. Phosphorylation at Tyr-387 disrupts interaction with APC. Phosphorylation at tyrosine residues by FYN inverts activity on modulation of BCL2L1 alternative splicing.; Acetylated. Positively correlates with ability to bind RNA.; Arginine methylation is required for nuclear localization. Also can affect interaction with other proteins. Inhibits interaction with Src-like SH3 domains, but not interaction with WW domains of WBP4/FBP21 AND FNBP4/FBP30.

Protein cellular localization

Nucleus . Membrane .

Background

This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associated protein family. The encoded protein appears to have many functions and may be involved in a variety of cellular processes, including alternative splicing, cell cycle regulation, RNA 3′-end formation, tumorigenesis, and regulation of human immunodeficiency virus gene expression. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Signaling Intermediates>Sam 68
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize KHDRBS1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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