Rabbit polyclonal KIF2C antibody (A5449)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KIF2C antibody (A5449)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KIF2C antibody.

Alternative names:

Check alternative names for the antibody

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MCAK antibody, KNSL6 antibody
4930402F02Rik antibody|CT139 antibody|ESTM5 antibody|KIF 2C antibody|kif2c antibody|KIF2C_HUMAN antibody|Kinesein Family Member 2C antibody|Kinesin family member 2C antibody|kinesin like 6 (mitotic centromere associated kinesin) antibody|Kinesin like 6 antibody|Kinesin like protein 6 antibody|Kinesin like protein KIF2C antibody|Kinesin-like protein 6 antibody|Kinesin-like protein KIF2C antibody|KNS L6 antibody|KNSL 6 antibody|KNSL6 antibody|MCAK antibody|MGC11883 antibody|Mitotic centromere associated kinesin antibody|Mitotic centromere-associated kinesin antibody|OTTHUMP00000010066 antibody|X83316 antibody|Anti-MCAK antibody [EPR14838] (ab187652)

SCBT cat No: sc-81305|sc-30277|

Name

Rabbit polyclonal KIF2C antibody

Catalogue No.

A5449

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KIF2C

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 81kDa/Observed: Refer to Figures

Formulation

KIF2C antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KIF2C antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MCAK antibody, KNSL6 antibody

Database links

Human UniProt/Swiss-Prot:Q99661

Protein names

MCAK, KNSL6

Protein function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis.

Protein tissue specificity

Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific.

Protein sequence and domain

The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends.Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.; Contains 1 kinesin motor domain.

Protein post-translational modifications

Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity.; Ubiquitinated.

Protein cellular localization

Cytoplasm, cytoskeleton . Nucleus . Chromosome, centromere. Chromosome, centromere, kinetochore. Note: Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2.

Background

The protein encoded by this gene is a member of kinesin-like protein family. Proteins of this family are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein is important for anaphase chromosome segregation and may be required to coordinate the onset of sister centromere separation.

Research area

All research areas>Structural Proteins>KIF
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize KIF2C antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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