Rabbit polyclonal KIR3DL1 antibody (A1617)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KIR3DL1 antibody (A1617)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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KIR antibody, NKB1 antibody, NKAT3 antibody, NKB1B antibody, CD158E1 antibody, KIR3DL1/S1 antibody
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SCBT cat No: sc-514336|sc-515229|

Name

Rabbit polyclonal KIR3DL1 antibody

Catalogue No.

A1617

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human KIR3DL1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 49kDa/Observed: Refer to Figures

Formulation

KIR3DL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KIR3DL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KIR antibody, NKB1 antibody, NKAT3 antibody, NKB1B antibody, CD158E1 antibody, KIR3DL1/S1 antibody

Database links

Human UniProt/Swiss-Prot:P43629

Protein names

KIR, NKB1, NKAT3, NKB1B, CD158E1, KIR3DL1/S1

Protein function

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

Protein sequence and domain

Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.Belongs to the immunoglobulin superfamily.; Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Protein cellular localization

Cell membrane; Single-pass type I membrane protein.

Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several “framework” genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Research area

All research areas>Lymphocyte Signaling>KIRD
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize KIR3DL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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