Rabbit polyclonal KLK7 antibody (A5506)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal KLK7 antibody (A5506)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KLK7 antibody.

Alternative names:

Check alternative names for the antibody

Expand

hK7 antibody, SCCE antibody, PRSS6 antibody
Chymotryptic stratum corneum antibody|Kallikrein-7 antibody|Kallikrein7 antibody|KLK 7 antibody|Klk7 antibody|KLK7_HUMAN antibody|Protease serine 6 antibody|PRSS 6 antibody|PRSS6 antibody|SCCE antibody|Serine protease 6 antibody|Signal protein antibody|Stratum corneum chymotryptic enzyme antibody|Anti-Kallikrein 7 antibody (ab200745)

SCBT cat No: sc-80148|sc-20381|sc-20380|sc-514447|sc-20625|

Name

Rabbit polyclonal KLK7 antibody

Catalogue No.

A5506

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human KLK7

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 27kDa/Observed: Refer to Figures

Formulation

KLK7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KLK7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

hK7 antibody, SCCE antibody, PRSS6 antibody

Database links

Human UniProt/Swiss-Prot:P49862

Protein names

hK7, SCCE, PRSS6

Protein function

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at ’14-Tyr-, -Gln-15′ and insulin B chain at ‘6-Leu-, -Cys-7′, ’16-Tyr-, -Leu-17′, ’25-Phe-, -Tyr-26′ and ’26-Tyr-, -Thr-27’. Could play a role in the activation of precursors to inflammatory cytokines.

Protein tissue specificity

Abundantly expressed in the skin and is expressed by keratinocytes in the epidermis. Also expressed in the brain, mammary gland, cerebellum, spinal cord and kidney. Lower levels in salivary glands, uterus, thymus, thyroid, placenta, trachea and testis. Up-regulated in ovarian carcinoma, especially late-stage serous carcinoma, compared with normal ovaries and benign adenomas (at protein level).

Protein sequence and domain

Belongs to the peptidase S1 family. Kallikrein subfamily.; Contains 1 peptidase S1 domain.

Protein cellular localization

Secreted . Note: In ovarian carcinoma, secreted and also observed at the apical membrane and in cytoplasm at the invasive front.

Background

This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19.

Research area

All research areas>Synthesis and Degradation>KLK
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize KLK7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!