Rabbit polyclonal KLKB1 antibody (A5318)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KLKB1 antibody (A5318)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KLKB1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

PPK antibody, KLK3 antibody
Fletcher factor antibody|kallikrein B plasma antibody|Kallikrein B plasma (Fletcher factor) 1 antibody|Kallikrein B, plasma 1 antibody|Kininogenin antibody|KLK3 antibody|KLKB1 antibody|KLKB1_HUMAN antibody|Plasma kallikrein antibody|Plasma kallikrein B1 antibody|Plasma kallikrein light chain antibody|Plasma prekallikrein antibody|PPK antibody|Prekallikrein antibody|Anti-Plasma Kallikrein 1B antibody [13G11] (ab1006)

SCBT cat No: sc-25799|sc-59581|sc-80524|sc-23915|

Name

Rabbit polyclonal KLKB1 antibody

Catalogue No.

A5318

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KLKB1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 71kDa/Observed: Refer to Figures

Formulation

KLKB1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KLKB1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

PPK antibody, KLK3 antibody

Database links

Human UniProt/Swiss-Prot:P03952

Protein names

PPK, KLK3

Protein function

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Protein sequence and domain

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.; Contains 4 apple domains.; Contains 1 peptidase S1 domain.

Protein cellular localization

Secreted.

Background

Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.

Note

AntibodyPlus can customize KLKB1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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