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Rabbit polyclonal KLKB1 antibody (A5318)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal KLKB1 antibody.
Check alternative names for the antibodyExpand
PPK antibody, KLK3 antibody
Fletcher factor antibody|kallikrein B plasma antibody|Kallikrein B plasma (Fletcher factor) 1 antibody|Kallikrein B, plasma 1 antibody|Kininogenin antibody|KLK3 antibody|KLKB1 antibody|KLKB1_HUMAN antibody|Plasma kallikrein antibody|Plasma kallikrein B1 antibody|Plasma kallikrein light chain antibody|Plasma prekallikrein antibody|PPK antibody|Prekallikrein antibody|Anti-Plasma Kallikrein 1B antibody [13G11] (ab1006)
SCBT cat No: sc-25799|sc-59581|sc-80524|sc-23915|
Rabbit polyclonal KLKB1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human KLKB1
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 71kDa/Observed: Refer to Figures
KLKB1 antibody was tube-contained.
KLKB1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
PPK antibody, KLK3 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
|Protein sequence and domain|| |
Belongs to the peptidase S1 family. Plasma kallikrein subfamily.; Contains 4 apple domains.; Contains 1 peptidase S1 domain.
|Protein cellular localization|| |
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
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|Product type|| |
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