Rabbit polyclonal KNG1 antibody (A1670)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KNG1 antibody (A1670)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KNG1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

BDK antibody, KNG antibody
Alpha-2-thiol proteinase inhibitor antibody|BDK antibody|BK antibody|Fitzgerald factor antibody|High molecular weight kininogen antibody|HMWK antibody|Ile-Ser-Bradykinin antibody|Kallidin I antibody|Kallidin II antibody|Kininogen 1 antibody|KNG antibody|KNG1 antibody|KNG1_HUMAN antibody|LMW antibody|Low molecular weight growth-promoting factor antibody|Low molecular weight kininogen antibody|Williams-Fitzgerald-Flaujeac factor antibody|Anti-Kininogen 1 antibody [EPR6097] (ab124737)

SCBT cat No: sc-293304|sc-14941|sc-293196|sc-15045|sc-25484|sc-15048|sc-15041|sc-15043|sc-136216|

Name

Rabbit polyclonal KNG1 antibody

Catalogue No.

A1670

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human KNG1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 72kDa/Observed: Refer to Figures

Formulation

KNG1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KNG1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BDK antibody, KNG antibody

Database links

Human UniProt/Swiss-Prot:P01042

Protein names

BDK, KNG

Protein function

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Protein tissue specificity

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

Protein sequence and domain

Contains 3 cystatin kininogen-type domains.

Protein post-translational modifications

Bradykinin is released from kininogen by plasma kallikrein.; Hydroxylation of Pro-383 occurs prior to the release of bradykinin.; Phosphorylated by FAM20C in the extracellular medium.; N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

Protein cellular localization

Secreted, extracellular space.

Background

Kininogens are inhibitors of thiol proteases. Kininogen 1 plays important role in Kinin-kallikrein system. This gene is translated into High-molecular weight kininogen (HMWK) and low-molecular weight kininogen (LMWK) after alternative splicing. HMWK is produced by the liver together with prekallikrein. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. LMWK is produced locally by numerous tissues, and secreted together with tissue kallikrein. 11926-1-AP was generated against N-terminal 300 aa of HMW kininogen. It can bind both HMW and LMW kiniogen.

Note

AntibodyPlus can customize KNG1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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