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Rabbit polyclonal KNG1 antibody (A1670)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal KNG1 antibody.
Check alternative names for the antibodyExpand
BDK antibody, KNG antibody
Alpha-2-thiol proteinase inhibitor antibody|BDK antibody|BK antibody|Fitzgerald factor antibody|High molecular weight kininogen antibody|HMWK antibody|Ile-Ser-Bradykinin antibody|Kallidin I antibody|Kallidin II antibody|Kininogen 1 antibody|KNG antibody|KNG1 antibody|KNG1_HUMAN antibody|LMW antibody|Low molecular weight growth-promoting factor antibody|Low molecular weight kininogen antibody|Williams-Fitzgerald-Flaujeac factor antibody|Anti-Kininogen 1 antibody [EPR6097] (ab124737)
SCBT cat No: sc-293304|sc-14941|sc-293196|sc-15045|sc-25484|sc-15048|sc-15041|sc-15043|sc-136216|
Rabbit polyclonal KNG1 antibody
|Catalogue No.|| |
Recombinant protein of human KNG1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 72kDa/Observed: Refer to Figures
KNG1 antibody was tube-contained.
KNG1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
BDK antibody, KNG antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.
|Protein tissue specificity|| |
Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.
|Protein sequence and domain|| |
Contains 3 cystatin kininogen-type domains.
|Protein post-translational modifications|| |
Bradykinin is released from kininogen by plasma kallikrein.; Hydroxylation of Pro-383 occurs prior to the release of bradykinin.; Phosphorylated by FAM20C in the extracellular medium.; N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
|Protein cellular localization|| |
Secreted, extracellular space.
Kininogens are inhibitors of thiol proteases. Kininogen 1 plays important role in Kinin-kallikrein system. This gene is translated into High-molecular weight kininogen (HMWK) and low-molecular weight kininogen (LMWK) after alternative splicing. HMWK is produced by the liver together with prekallikrein. It acts mainly as a cofactor on coagulation and inflammation, and has no intrinsic catalytic activity. LMWK is produced locally by numerous tissues, and secreted together with tissue kallikrein. 11926-1-AP was generated against N-terminal 300 aa of HMW kininogen. It can bind both HMW and LMW kiniogen.
AntibodyPlus can customize KNG1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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