Rabbit polyclonal KPNA3 antibody (A8347)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KPNA3 antibody (A8347)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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SRP1 antibody, SRP4 antibody, IPOA4 antibody, hSRP1 antibody, SRP1gamma antibody
SRP1 gamma antibody|hSRP1 antibody|IMA4_HUMAN antibody|Importin alpha 3 antibody|Importin alpha 3 subunit antibody|Importin alpha 4 antibody|Importin alpha Q2 antibody|Importin subunit alpha-4 antibody|IPOA4 antibody|Karyopherin alpha 3 antibody|Karyopherin alpha 3 importin alpha 4 antibody|Karyopherin alpha 3 subunit antibody|Karyopherin subunit alpha 3 antibody|Karyopherin subunit alpha-3 antibody|KPNA 3 antibody|Kpna3 antibody|Qip2 antibody|SRP1 antibody|SRP1-gamma antibody|SRP1gamma antibody|SRP4 antibody|Anti-KPNA3 antibody (ab6038)

SCBT cat No: sc-514101|

Name

Rabbit polyclonal KPNA3 antibody

Catalogue No.

A8347

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human KPNA3

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 58kDa/Observed: Refer to figures

Formulation

KPNA3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KPNA3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SRP1 antibody, SRP4 antibody, IPOA4 antibody, hSRP1 antibody, SRP1gamma antibody

Database links

Human UniProt/Swiss-Prot:O00505

Protein names

SRP1, SRP4, IPOA4, hSRP1, SRP1gamma

Protein function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9.

Protein tissue specificity

Ubiquitous. Highest levels in heart and skeletal muscle.

Protein sequence and domain

Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.; The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).; The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).Belongs to the importin alpha family.; Contains 10 ARM repeats.; Contains 1 IBB domain.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import.

Research area

All research areas>Transport and Trafficking>karyopherin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus can customize KPNA3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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