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Rabbit polyclonal KPNA4 antibody (A2026)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal KPNA4 antibody.
Check alternative names for the antibodyExpand
QIP1 antibody, SRP3 antibody, IPOA3 antibody
FLJ31113 antibody|IMA3_HUMAN antibody|Importin alpha 3 antibody|Importin alpha 4 subunit antibody|Importin alpha Q1 antibody|Importin subunit alpha 3 antibody|Importin subunit alpha-3 antibody|IPO A3 antibody|IPOA 3 antibody|IPOA3 antibody|Karyopherin alpha 4 (importin alpha 3) antibody|Karyopherin alpha 4 antibody|Karyopherin alpha 4 importin alpha 3 antibody|Karyopherin alpha 4 subunit antibody|Karyopherin subunit alpha 4 antibody|Karyopherin subunit alpha-4 antibody|KPNA 4 antibody|Kpna4 antibody|MGC12217 antibody|MGC26703 antibody|OTTHUMP00000213880 antibody|QIP 1 antibody|Qip1 antibody|Qip1 protein antibody|SRP 3 antibody|SRP3 antibody|Anti-KPNA4 antibody (ab6039)
SCBT cat No: sc-101547|sc-390535|sc-55266|sc-366197|sc-55270|
Rabbit polyclonal KPNA4 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human KPNA4
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 57kDa/Observed: Refer to Figures
KPNA4 antibody was tube-contained.
KPNA4 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
QIP1 antibody, SRP3 antibody, IPOA3 antibody
|Database links|| |
|Protein names|| |
QIP1, SRP3, IPOA3
|Protein function|| |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
|Protein tissue specificity|| |
Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.
|Protein sequence and domain|| |
Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.; The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).; The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).Belongs to the importin alpha family.; Contains 10 ARM repeats.; Contains 1 IBB domain.
|Protein cellular localization|| |
Cytoplasm . Nucleus .
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
AntibodyPlus can customize KPNA4 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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