Rabbit polyclonal KPNA4 antibody (A2026)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KPNA4 antibody (A2026)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KPNA4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

QIP1 antibody, SRP3 antibody, IPOA3 antibody
FLJ31113 antibody|IMA3_HUMAN antibody|Importin alpha 3 antibody|Importin alpha 4 subunit antibody|Importin alpha Q1 antibody|Importin subunit alpha 3 antibody|Importin subunit alpha-3 antibody|IPO A3 antibody|IPOA 3 antibody|IPOA3 antibody|Karyopherin alpha 4 (importin alpha 3) antibody|Karyopherin alpha 4 antibody|Karyopherin alpha 4 importin alpha 3 antibody|Karyopherin alpha 4 subunit antibody|Karyopherin subunit alpha 4 antibody|Karyopherin subunit alpha-4 antibody|KPNA 4 antibody|Kpna4 antibody|MGC12217 antibody|MGC26703 antibody|OTTHUMP00000213880 antibody|QIP 1 antibody|Qip1 antibody|Qip1 protein antibody|SRP 3 antibody|SRP3 antibody|Anti-KPNA4 antibody (ab6039)

SCBT cat No: sc-101547|sc-390535|sc-55266|sc-366197|sc-55270|

Name

Rabbit polyclonal KPNA4 antibody

Catalogue No.

A2026

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KPNA4

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 57kDa/Observed: Refer to Figures

Formulation

KPNA4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KPNA4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

QIP1 antibody, SRP3 antibody, IPOA3 antibody

Database links

Human UniProt/Swiss-Prot:O00629

Protein names

QIP1, SRP3, IPOA3

Protein function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Protein tissue specificity

Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes.

Protein sequence and domain

Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.; The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).; The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).Belongs to the importin alpha family.; Contains 10 ARM repeats.; Contains 1 IBB domain.

Protein cellular localization

Cytoplasm . Nucleus .

Background

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.

Note

AntibodyPlus can customize KPNA4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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