Rabbit polyclonal KPNA5 antibody (A7331)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KPNA5 antibody (A7331)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KPNA5 antibody.

Alternative names:

Check alternative names for the antibody

Expand

SRP6 antibody, IPOA6 antibody
IMA5_HUMAN antibody|Importin alpha 1 subunit antibody|Importin alpha 5 antibody|Importin alpha S1 antibody|Importin subunit alpha-5, N-terminally processed antibody|IPO A5 antibody|IPOA 5 antibody|IPOA5 antibody|Karyopherin alpha 1 antibody|Karyopherin alpha 1 subunit antibody|Karyopherin subunit alpha-1 antibody|KPNA 1 antibody|KPNA1 antibody|mSRP 1 antibody|mSRP1 antibody|NPI 1 antibody|NPI-1 antibody|NPI1 antibody|Nucleoprotein interactor 1 antibody|RAG cohort protein 2 antibody|RCH 2 antibody|RCH2 antibody|Recombination activating gene cohort 2 antibody|SRP 1 antibody|SRP1 beta antibody|SRP1-beta antibody|Anti-KPNA5 antibody – N-terminal (ab189987)

SCBT cat No: sc-517105|sc-68194|sc-68195|

Name

Rabbit polyclonal KPNA5 antibody

Catalogue No.

A7331

Reactivity

Human

Immunogen

Recombinant protein of human KPNA5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to figures

Formulation

KPNA5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KPNA5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

SRP6 antibody, IPOA6 antibody

Database links

Human UniProt/Swiss-Prot:O15131

Protein names

SRP6, IPOA6

Protein function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Protein tissue specificity

Testis.

Protein sequence and domain

Consists of an N-terminal hydrophilic region, a hydrophobic central region composed of 10 repeats, and a short hydrophilic C-terminus. The N-terminal hydrophilic region contains the importin beta binding domain (IBB domain), which is sufficient for binding importin beta and essential for nuclear protein import.; The IBB domain is thought to act as an intrasteric autoregulatory sequence by interacting with the internal autoinhibitory NLS. Binding of KPNB1 probably overlaps the internal NLS and contributes to a high affinity for cytoplasmic NLS-containing cargo substrates. After dissociation of the importin/substrate complex in the nucleus the internal autohibitory NLS contributes to a low affinity for nuclear NLS-containing proteins (By similarity).; The major and minor NLS binding sites are mainly involved in recognition of simple or bipartite NLS motifs. Structurally located within in a helical surface groove they contain several conserved Trp and Asn residues of the corresponding third helices (H3) of ARM repeats which mainly contribute to binding (By similarity).Belongs to the importin alpha family.; Contains 10 ARM repeats.; Contains 1 IBB domain.

Protein cellular localization

Cytoplasm.

Background

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.

Research area

All research areas>Transport and Trafficking>karyopherin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus can customize KPNA5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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