Rabbit polyclonal KPNA6 antibody (A7363)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KPNA6 antibody (A7363)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal KPNA6 antibody.

Alternative names:

Check alternative names for the antibody

Expand

IPOA7 antibody, KPNA7 antibody
FLJ11249 antibody|IMA7_HUMAN antibody|Importin alpha 7 subunit antibody|Importin alpha S2 antibody|Importin subunit alpha 7 antibody|Importin subunit alpha-7 antibody|IPOA 7 antibody|IPOA7 antibody|Karyopherin alpha 6 antibody|Karyopherin alpha 6 (importin alpha 7) antibody|Karyopherin subunit alpha 6 antibody|Karyopherin subunit alpha-6 antibody|KPNA 6 antibody|KPNA 7 antibody|Kpna6 antibody|KPNA7 antibody|MGC17918 antibody|OTTHUMP00000004532 antibody|Anti-KPNA6 antibody (ab110016)

SCBT cat No: sc-68197|sc-390055|

Name

Rabbit polyclonal KPNA6 antibody

Catalogue No.

A7363

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human KPNA6

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 60kDa/Observed: Refer to figures

Formulation

KPNA6 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KPNA6 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IPOA7 antibody, KPNA7 antibody

Database links

Human UniProt/Swiss-Prot:O60684

Protein names

IPOA7, KPNA7

Protein function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

Belongs to the importin alpha family.; Contains 10 ARM repeats.; Contains 1 IBB domain.

Background

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.

Research area

All research areas>Transport and Trafficking>karyopherin
(View all antibody categories related to Transport and Trafficking)

Note

AntibodyPlus can customize KPNA6 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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