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Rabbit polyclonal KPNA6 antibody (A7363)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal KPNA6 antibody.
Check alternative names for the antibodyExpand
IPOA7 antibody, KPNA7 antibody
FLJ11249 antibody|IMA7_HUMAN antibody|Importin alpha 7 subunit antibody|Importin alpha S2 antibody|Importin subunit alpha 7 antibody|Importin subunit alpha-7 antibody|IPOA 7 antibody|IPOA7 antibody|Karyopherin alpha 6 antibody|Karyopherin alpha 6 (importin alpha 7) antibody|Karyopherin subunit alpha 6 antibody|Karyopherin subunit alpha-6 antibody|KPNA 6 antibody|KPNA 7 antibody|Kpna6 antibody|KPNA7 antibody|MGC17918 antibody|OTTHUMP00000004532 antibody|Anti-KPNA6 antibody (ab110016)
SCBT cat No: sc-68197|sc-390055|
Rabbit polyclonal KPNA6 antibody
|Catalogue No.|| |
Recombinant protein of human KPNA6
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 60kDa/Observed: Refer to figures
KPNA6 antibody was tube-contained.
KPNA6 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
IPOA7 antibody, KPNA7 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
|Protein tissue specificity|| |
|Protein sequence and domain|| |
Belongs to the importin alpha family.; Contains 10 ARM repeats.; Contains 1 IBB domain.
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family.
AntibodyPlus can customize KPNA6 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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