Rabbit polyclonal KRT17 antibody (A2175)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal KRT17 antibody (A2175)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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K17 antibody, PC antibody, PC2 antibody, PCHC1 antibody
39.1 antibody|CK 17 antibody|CK-17 antibody|Cytokeratin-17 antibody|K17 antibody|K1C17_HUMAN antibody|Keratin 17 antibody|keratin 17 epitope S1 antibody|keratin 17 epitope S2 antibody|keratin 17 epitope S4 antibody|Keratin 17, type I antibody|Keratin antibody|Keratin type I cytoskeletal 17 antibody|keratin, type i cytoskeletal 17 [version 1] antibody|Keratin-17 antibody|KRT17 antibody|PC antibody|PC2 antibody|PCHC1 antibody|type I cytoskeletal 17 antibody|Anti-Cytokeratin 17 antibody [EP1623] – Cytoskeleton Marker (ab109725)

SCBT cat No: sc-393091|sc-58726|sc-393002|sc-366511|sc-101461|

Name

Rabbit polyclonal KRT17 antibody

Catalogue No.

A2175

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human KRT17

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 48kDa/Observed: Refer to Figures

Formulation

KRT17 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

KRT17 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

K17 antibody, PC antibody, PC2 antibody, PCHC1 antibody

Database links

Human UniProt/Swiss-Prot:Q04695

Protein names

K17, PC, PC2, PCHC1

Protein function

Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial “stem cells”. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation.

Protein tissue specificity

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

Protein sequence and domain

Belongs to the intermediate filament family.

Protein post-translational modifications

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

Protein cellular localization

Cytoplasm .

Background

Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).Keratin 17 is involved in wound healing and cell growth, two processes that require rapid cytoskeletal remodeling (7). Keratinocytes deficient in keratin 17 exhibit abnormal Akt/mTOR signaling and fail to produce an increase in translation, cell size, or growth; these cells also exhibit abnormal 14-3-3sigma localization. As 14-3-3sigma typically associates with keratin 17, these results imply that Akt/mTOR signaling results in sequestration of 14-3-3sigma with keratin 17 in the cytosol, which is required for translation and cell growth. Phosphorylation of keratin 17 on Ser44 may provide a docking site for 14-3-3sigma binding (8).

Research area

All research areas>Structural Proteins>Cytokeratin
(View all antibody categories related to Structural Proteins)

Note

AntibodyPlus can customize KRT17 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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