Rabbit polyclonal LAMTOR5 antibody (A2606)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal LAMTOR5 antibody (A2606)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal LAMTOR5 antibody.

Alternative names:

Check alternative names for the antibody

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LAMTOR5 antibody,HBXIP antibody,XIP antibody,Ragulator complex protein LAMTOR5 antibody
HBV X interacting protein antibody|HBV X-interacting protein antibody|HBX interacting protein antibody|HBX-interacting protein antibody|hbxip antibody|HBXIP_HUMAN antibody|Hepatitis B virus X interacting protein antibody|Hepatitis B virus X-interacting protein antibody|LAMTOR5 antibody|Late endosomal/lysosomal adaptor MAPK and MTOR activator 5 antibody|MGC71071 antibody|Ragulator complex protein LAMTOR5 antibody|XIP antibody|Anti-HBXIP antibody [EPR11531(B)] (ab157480)

SCBT cat No: sc-54080|sc-134791|sc-373980|

Name

Rabbit polyclonal LAMTOR5 antibody

Catalogue No.

A2606

Reactivity

Human, Mouse

Immunogen

Recombinant Protein of human LAMTOR5

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 10kDa/Observed: Refer to Figures

Formulation

LAMTOR5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LAMTOR5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LAMTOR5 antibody,HBXIP antibody,XIP antibody,Ragulator complex protein LAMTOR5 antibody

Database links

Human UniProt/Swiss-Prot:O43504

Protein names

LAMTOR5,HBXIP,XIP,Ragulator complex protein LAMTOR5

Protein function

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication.

Protein tissue specificity

Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung. Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection compared with hepatic tissue without HBV infection.

Protein sequence and domain

Belongs to the LAMTOR5 family.

Protein cellular localization

Cytoplasm. Lysosome.

Background

HBXIP, also named as XIP, belongs to the HBXIP family. It is originally identified by its interaction with the C-terminus of hepatitis B virus (HBV) X protein (HBx). HBXIP is a regulator of centrosome dynamics and cytokinesis. HBXIP is able to up-regulate S100A4 though activating STAT4 and inducing DNA methylation of PTEN. HBXIP is a cellular 18kd protein and cytoplasm stain.

Note

AntibodyPlus can customize LAMTOR5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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