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Rabbit polyclonal LCP2 antibody (A2567)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal LCP2 antibody.
Check alternative names for the antibodyExpand
SLP76 antibody, SLP-76 antibody
76 kDa tyrosine phosphoprotein antibody|CG8697 antibody|LCP 2 antibody|LCP2 antibody|LCP2_HUMAN antibody|Lymphocyte cytosolic protein 2 antibody|SH2 domain containing leukocyte protein 76 KD antibody|SH2 domain containing leukocyte protein of 76kD antibody|SH2 domain containing leukocyte protein of 76kDa antibody|SH2 domain-containing leukocyte protein of 76 kDa antibody|SLP 76 antibody|SLP 76 tyrosine phosphoprotein antibody|SLP-76 antibody|SLP-76 tyrosine phosphoprotein antibody|SLP76 antibody|SLP76 tyrosine phosphoprotein antibody|Anti-SLP76 antibody [EPR2549(2)] (ab109254)
SCBT cat No:
Rabbit polyclonal LCP2 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human LCP2
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 60kDa/Observed: Refer to Figures
LCP2 antibody was tube-contained.
LCP2 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
SLP76 antibody, SLP-76 antibody
|Database links|| |
|Protein names|| |
|Protein function|| |
Involved in T-cell antigen receptor mediated signaling.
|Protein tissue specificity|| |
Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblastoma cell lines.
|Protein sequence and domain|| |
The SH2 domain mediates interaction with phosphorylated CD6 . The SH2 domain mediates interaction with SHB .Contains 1 SAM (sterile alpha motif) domain.; Contains 1 SH2 domain.
|Protein post-translational modifications|| |
Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components.
|Protein cellular localization|| |
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
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|Product type|| |
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