Rabbit polyclonal LDLRAP1 antibody (A7093)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal LDLRAP1 antibody (A7093)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal LDLRAP1 antibody.

Alternative names:

Check alternative names for the antibody

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ARH antibody, ARH1 antibody, ARH2 antibody, FHCB1 antibody, FHCB2 antibody
ARH antibody|ARH GENE antibody|ARH_HUMAN antibody|ARH1 antibody|ARH2 antibody|Autosomal recessive hypercholesterolemia protein antibody|DKFZp586D0624 antibody|FHCB1 antibody|FHCB2 antibody|LDL receptor adaptor protein antibody|Ldlrap1 antibody|Low density lipoprotein receptor adapter protein 1 antibody|MGC34705 antibody|OTTHUMP00000008526 antibody|Anti-ARH antibody (ab57261)

SCBT cat No: sc-514263|sc-514106|sc-292294|sc-100653|

Name

Rabbit polyclonal LDLRAP1 antibody

Catalogue No.

A7093

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human LDLRAP1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 34kDa/Observed: Refer to figures

Formulation

LDLRAP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LDLRAP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ARH antibody, ARH1 antibody, ARH2 antibody, FHCB1 antibody, FHCB2 antibody

Database links

Human UniProt/Swiss-Prot:Q5SW96

Protein names

ARH, ARH1, ARH2, FHCB1, FHCB2

Protein function

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.

Protein tissue specificity

Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.

Protein sequence and domain

The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.Contains 1 PID domain.

Protein cellular localization

Cytoplasm .

Background

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Note

AntibodyPlus can customize LDLRAP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


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Antibody customer reviews & validation data - 43

Validation data ID: 43

Submission date: 2016-12-23

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Result figure:
Result figure

Figure description:

Cultured keratinocytes were transfected with GFP-LDLRAP1 and immunoblotted with A7093 ABclonal LDLRAP1 Polyclonal antibody or a homemade anti-GFP antibody. The LDLRAP1 antibody detects a target band of around 38 kDa in untransfected keratinocytes and an additional band of 68 kDa in GFP-LDLRAP1 transfected keratinocytes.

Product name

LDLRAP1 Polyclonal Antibody

Product catalog No.

A7093

Product type

Primary antibody

Supplier

ABclonal

Application type

Western Blot

Antibody specificity rating

Excellent

Antibody overall rating

Excellent

Your comments

LDLRAP1 Polyclonal Antibody works very well both for western blot and immunofluorescence (IF).

Detailed protocol

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