Rabbit polyclonal LIG3 antibody (A1887)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal LIG3 antibody (A1887)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal LIG3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

LIG2 antibody, LIG3 antibody
D11Wsu78e antibody|DNA ligase antibody|DNA ligase 3 antibody|DNA ligase III antibody|DNLI3_HUMAN antibody|LIG 3 antibody|LIG2 antibody|LIG3 antibody|Ligase II, DNA, ATP dependent antibody|Ligase III DNA ATP dependent antibody|MGC78176 antibody|OTTMUSP00000000875 antibody|Polydeoxyribonucleotide synthase [ATP] 3 antibody|Polydeoxyribonucleotide synthase [ATP] antibody|Polydeoxyribonucleotide synthase antibody|RP23-316C11.6 antibody|Anti-DNA Ligase III antibody [6G9] (ab587)

SCBT cat No: sc-56089|sc-135883|sc-390922|sc-292772|

Name

Rabbit polyclonal LIG3 antibody

Catalogue No.

A1887

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human LIG3

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 113kDa/Observed: Refer to Figures

Formulation

LIG3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LIG3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LIG2 antibody, LIG3 antibody

Database links

Human UniProt/Swiss-Prot:P49916

Protein names

LIG2, LIG3

Protein function

Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair .

Protein tissue specificity

Testis, thymus, prostate and heart.

Protein sequence and domain

The PARP-type zinc finger is required for DNA ligase activity.Belongs to the ATP-dependent DNA ligase family.; Contains 1 BRCT domain.; Contains 1 PARP-type zinc finger.

Protein cellular localization

Isoform 1: Mitochondrion . Note: Contains an N-terminal mitochondrial transit peptide.; Isoform 2: Mitochondrion . Note: Contains an N-terminal mitochondrial transit peptide.; Isoform 3: Nucleus . Note: Lacks the N-terminal mitochondrial transit peptide.; Isoform 4: Nucleus . Note: Lacks the N-terminal mitochondrial transit peptide.

Background

This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Research area

All research areas>Tumor Suppressor/Apoptosis>DNA Ligase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize LIG3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!