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Rabbit polyclonal LIG4 antibody (A1743)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
WB 1:500 – 1:2000 IHC 1:50 – 1:200
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal LIG4 antibody.
Check alternative names for the antibodyExpand
DNA ligase IV ATP dependent antibody|DNA joinase antibody|DNA ligase 4 antibody|DNA ligase IV antibody|DNA repair enzyme antibody|DNLI4_HUMAN antibody|LIG 4 antibody|LIG4 antibody|LIG4S antibody|Ligase IV antibody|Ligase IV DNA ATP dependent antibody|Polydeoxyribonucleotide synthase [ATP] 4 antibody|Polydeoxyribonucleotide synthase 4 antibody|Polydeoxyribonucleotide synthase antibody|Polynucleotide ligase antibody|Sealase antibody|Anti-DNA Ligase IV antibody (ab26039)
SCBT cat No: sc-11750|sc-271299|sc-28232|sc-11748|
Rabbit polyclonal LIG4 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human LIG4
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 104kDa/Observed: Refer to Figures
LIG4 antibody was tube-contained.
LIG4 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
|Protein tissue specificity|| |
Testis, thymus, prostate and heart.
|Protein sequence and domain|| |
Belongs to the ATP-dependent DNA ligase family.; Contains 2 BRCT domains.
|Protein cellular localization|| |
Two major pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), counteract one of themost toxic lesions, the DSB. The core protein complex mediating NHEJ in mammals includes DNA ligase IV (Lig4). Lig4 belongs to an ATP-dependent DNA ligase family, and joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. The complex Lig4-XRCC4 is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of Lig4.
AntibodyPlus can customize LIG4 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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