Rabbit polyclonal LIG4 antibody (A1743)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal LIG4 antibody (A1743)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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LIG4 antibody
DNA ligase IV ATP dependent antibody|DNA joinase antibody|DNA ligase 4 antibody|DNA ligase IV antibody|DNA repair enzyme antibody|DNLI4_HUMAN antibody|LIG 4 antibody|LIG4 antibody|LIG4S antibody|Ligase IV antibody|Ligase IV DNA ATP dependent antibody|Polydeoxyribonucleotide synthase [ATP] 4 antibody|Polydeoxyribonucleotide synthase 4 antibody|Polydeoxyribonucleotide synthase antibody|Polynucleotide ligase antibody|Sealase antibody|Anti-DNA Ligase IV antibody (ab26039)

SCBT cat No: sc-11750|sc-271299|sc-28232|sc-11748|

Name

Rabbit polyclonal LIG4 antibody

Catalogue No.

A1743

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human LIG4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 104kDa/Observed: Refer to Figures

Formulation

LIG4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LIG4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LIG4 antibody

Database links

Human UniProt/Swiss-Prot:P49917

Protein names

LIG4

Protein function

Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Protein tissue specificity

Testis, thymus, prostate and heart.

Protein sequence and domain

Belongs to the ATP-dependent DNA ligase family.; Contains 2 BRCT domains.

Protein cellular localization

Nucleus.

Background

Two major pathways, homologous recombination (HR) and nonhomologous end joining (NHEJ), counteract one of themost toxic lesions, the DSB. The core protein complex mediating NHEJ in mammals includes DNA ligase IV (Lig4). Lig4 belongs to an ATP-dependent DNA ligase family, and joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. The complex Lig4-XRCC4 is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of Lig4.

Research area

All research areas>Tumor Suppressor/Apoptosis>DNA Ligase
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize LIG4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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