Rabbit polyclonal LILRB4 antibody (A7073)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal LILRB4 antibody (A7073)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal LILRB4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

ILT3 antibody, LIR5 antibody, CD85K antibody, ILT-3 antibody, LIR-5 antibody
CD85 antigen-like family member K antibody|CD85k antibody|HM18 antibody|ILT-3 antibody|ILT3 antibody|Immunoglobulin-like transcript 3 antibody|Leukocyte immunoglobulin like receptor subfamily B (with TM and ITIM domains) member 4 antibody|Leukocyte immunoglobulin-like receptor 5 antibody|Leukocyte immunoglobulin-like receptor subfamily B member 4 antibody|LILRB4 antibody|LILRB5 antibody|LIR-5 antibody|LIR5 antibody|LIRB4_HUMAN antibody|Monocyte inhibitory receptor HM18 antibody|Anti-LILRB4 antibody (ab129772)

SCBT cat No: sc-366213|

Name

Rabbit polyclonal LILRB4 antibody

Catalogue No.

A7073

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human LILRB4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 49kDa/Observed: Refer to figures

Formulation

LILRB4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LILRB4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ILT3 antibody, LIR5 antibody, CD85K antibody, ILT-3 antibody, LIR-5 antibody

Database links

Human UniProt/Swiss-Prot:Q8NHJ6

Protein names

ILT3, LIR5, CD85K, ILT-3, LIR-5

Protein function

Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

Protein tissue specificity

Detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells.

Protein sequence and domain

Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Protein cellular localization

Cell membrane ; Single-pass type I membrane protein . Note: Ligand binding leads to internalization and translocation to an antigen-processing compartment.

Background

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Lymphocyte Signaling>ILT
(View all antibody categories related to Lymphocyte Signaling)

Note

AntibodyPlus can customize LILRB4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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