Rabbit polyclonal LRP5 antibody (A0130)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal LRP5 antibody (A0130)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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LRP5 antibody,BMND1 antibody,EVR1 antibody,EVR4 antibody,HBM antibody,LR3 antibody,LRP7 antibody,OPPG antibody,OPS antibody,OPTA1 antibody,VBCH2 antibody
BMND1 antibody|LR3 antibody|LRP7 antibody|OPPG antibody|OPS antibody|OPTA1 antibody|VBCH2 antibody|Anti-LRP5 antibody (ab36121)

SCBT cat No: sc-390267|sc-21390|sc-514713|sc-21389|

Name

Rabbit polyclonal LRP5 antibody

Catalogue No.

A0130

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human LRP5

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 179kDa/Observed: Refer to Figures

Formulation

LRP5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LRP5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LRP5 antibody,BMND1 antibody,EVR1 antibody,EVR4 antibody,HBM antibody,LR3 antibody,LRP7 antibody,OPPG antibody,OPS antibody,OPTA1 antibody,VBCH2 antibody

Database links

Human UniProt/Swiss-Prot:O75197

Protein names

LRP5,BMND1,EVR1,EVR4,HBM,LR3,LRP7,OPPG,OPS,OPTA1,VBCH2

Protein function

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction . The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity). Required for posterior patterning of the epiblast during gastrulation (By similarity).

Protein tissue specificity

Widely expressed, with the highest level of expression in the liver and in aorta.

Protein sequence and domain

Belongs to the LDLR family.; Contains 4 EGF-like domains.; Contains 3 LDL-receptor class A domains.; Contains 20 LDL-receptor class B repeats.

Protein post-translational modifications

Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through acting as a docking site for AXIN1.

Protein cellular localization

Membrane; Single-pass type I membrane protein. Endoplasmic reticulum . Note: Chaperoned to the plasma membrane by MESD.

Background

LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain (1). They function as co-receptors for Wnt and are required for the canonical Wnt/beta-catenin signaling pathway (2,3). LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5). The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7). Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10). Phosphorylated LRP6 recruits axin to the membrane and presumably activates beta-catenin signaling (8-10).LRP5 is involved in the regulation of bone homeostasis. Mutations and polymorphisms in LPR5 are associated with bone diseases like osteoporosis-pseudoglioma syndrome and high-bone-mass disorders (11-13). In addition, mutations in LRP5 are found in patients with hyperparathyroid tumor and breast cancer (14,15).

Research area

All research areas>Membrane Receptors>LRP
(View all antibody categories related to Membrane Receptors)

Note

AntibodyPlus can customize LRP5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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