Rabbit polyclonal LRSAM1 antibody (A9885)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal LRSAM1 antibody (A9885)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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CMT2P antibody|E3 ubiquitin protein ligase LRSAM1 antibody|E3 ubiquitin-protein ligase LRSAM1 antibody|EC 6.3.2.- antibody|FLJ31641 antibody|hTAL antibody|Leucine rich repeat and sterile alpha motif containing 1 antibody|Leucine rich repeat and sterile alpha motif containing protein 1 antibody|Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody|LRSAM1 antibody|LRSM1_HUMAN antibody|OTTHUMP00000022174 antibody|OTTHUMP00000022175 antibody|RIFLE antibody|TAL antibody|Tsg101 associated ligase antibody|Tsg101-associated ligase antibody|Anti-LRSAM1 antibody (ab73113)

SCBT cat No: sc-139531|

Name

Rabbit polyclonal LRSAM1 antibody

Catalogue No.

A9885

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human LRSAM1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 84kDa/Observed: Refer to figures

Formulation

LRSAM1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

LRSAM1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q6UWE0

Protein function

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos . Bacterial recognition protein that defends the cytoplasm from invasive pathogens . Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) .

Protein tissue specificity

Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.

Protein sequence and domain

The coiled coil domains interact with the SB domain of TSG101.; The PTAP motifs mediate the binding to UEV domains.; The LRR domain is necessary and sufficient for localization to bacterial targets.; The RING domain is required for ubiquitination.Contains 6 LRR (leucine-rich) repeats.; Contains 1 RING-type zinc finger.; Contains 1 SAM (sterile alpha motif) domain.

Protein post-translational modifications

Ubiquitination promoted by PHF23 leads to proteasomal degradation.

Protein cellular localization

Cytoplasm . Note: Displays a punctuate distribution and localizes to a submembranal ring . Localizes to intracellular bacterial pathogens .

Note

AntibodyPlus can customize LRSAM1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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