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Rabbit polyclonal LRSAM1 antibody (A9885)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal LRSAM1 antibody.
Check alternative names for the antibodyExpand
CMT2P antibody|E3 ubiquitin protein ligase LRSAM1 antibody|E3 ubiquitin-protein ligase LRSAM1 antibody|EC 6.3.2.- antibody|FLJ31641 antibody|hTAL antibody|Leucine rich repeat and sterile alpha motif containing 1 antibody|Leucine rich repeat and sterile alpha motif containing protein 1 antibody|Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody|LRSAM1 antibody|LRSM1_HUMAN antibody|OTTHUMP00000022174 antibody|OTTHUMP00000022175 antibody|RIFLE antibody|TAL antibody|Tsg101 associated ligase antibody|Tsg101-associated ligase antibody|Anti-LRSAM1 antibody (ab73113)
SCBT cat No: sc-139531|
Rabbit polyclonal LRSAM1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human LRSAM1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 84kDa/Observed: Refer to figures
LRSAM1 antibody was tube-contained.
LRSAM1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos . Bacterial recognition protein that defends the cytoplasm from invasive pathogens . Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) .
|Protein tissue specificity|| |
Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
|Protein sequence and domain|| |
The coiled coil domains interact with the SB domain of TSG101.; The PTAP motifs mediate the binding to UEV domains.; The LRR domain is necessary and sufficient for localization to bacterial targets.; The RING domain is required for ubiquitination.Contains 6 LRR (leucine-rich) repeats.; Contains 1 RING-type zinc finger.; Contains 1 SAM (sterile alpha motif) domain.
|Protein post-translational modifications|| |
Ubiquitination promoted by PHF23 leads to proteasomal degradation.
|Protein cellular localization|| |
Cytoplasm . Note: Displays a punctuate distribution and localizes to a submembranal ring . Localizes to intracellular bacterial pathogens .
AntibodyPlus can customize LRSAM1 antibody according to your requirement, including bulk product size,etc. Please contact firstname.lastname@example.org. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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