Rabbit polyclonal MAD1L1 antibody (A1153)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAD1L1 antibody (A1153)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MAD1L1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

MAD1L1 antibody,HsMAD1 antibody,MAD1 antibody,PIG9 antibody,TP53I9 antibody,TXBP181 antibody
hMAD1 antibody|HsMAD1 antibody|MAD1 antibody|MAD1 mitotic arrest deficient like 1 (yeast) antibody|MAD1-like protein 1 antibody|MAD1L1 antibody|MD1L1_HUMAN antibody|Mitotic arrest deficient 1 antibody|Mitotic arrest deficient 1-like protein 1 antibody|Mitotic checkpoint MAD1 protein homolog antibody|Mitotic spindle assembly checkpoint protein MAD1 antibody|PIG9 antibody|Tax binding protein 181 antibody|Tax-binding protein 181 antibody|TP53I9 antibody|Tumor protein p53 inducible protein 9 antibody|TXBP181 antibody|Anti-MAD1 antibody (ab175245)

SCBT cat No: sc-65494|sc-65493|sc-47746|sc-137025|sc-166312|sc-166313|sc-137026|sc-376613|sc-166322|sc-67338|

Name

Rabbit polyclonal MAD1L1 antibody

Catalogue No.

A1153

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAD1L1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 83kDa/Observed: Refer to Figures

Formulation

MAD1L1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAD1L1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MAD1L1 antibody,HsMAD1 antibody,MAD1 antibody,PIG9 antibody,TP53I9 antibody,TXBP181 antibody

Database links

Human UniProt/Swiss-Prot:Q9Y6D9

Protein names

MAD1L1,HsMAD1,MAD1,PIG9,TP53I9,TXBP181

Protein function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Protein tissue specificity

Expressed weakly at G0/G1 and highly at late S and G2/M phase.

Protein sequence and domain

Belongs to the MAD1 family.

Protein post-translational modifications

Phosphorylated; by BUB1. Become hyperphosphorylated in late S through M phases or after mitotic spindle damage.

Protein cellular localization

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note: From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Colocalizes with NEK2 at the kinetochore.

Background

MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Research area

All research areas>Cell Cycle Proteins>MAD
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize MAD1L1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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