Rabbit polyclonal MAFB antibody (A10077)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAFB antibody (A10077)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Kreisler antibody|KRML antibody|Maf-B antibody|Mafb antibody|MAFB/Kreisler basic region/leucine zipper transcription factor antibody|MAFB_HUMAN antibody|MGC43127 antibody|Segmentation protein KR antibody|Transcription factor MafB antibody|V maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) antibody|V-maf musculoaponeurotic fibrosarcoma oncogene homolog B antibody|Anti-MafB antibody (ab66506)

SCBT cat No: sc-7866|sc-10017|sc-365023|sc-131130|sc-100486|sc-398296|

Name

Rabbit polyclonal MAFB antibody

Catalogue No.

A10077

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAFB

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 36kDa/Observed: Refer to figures

Formulation

MAFB antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAFB antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q9Y5Q3

Protein function

Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context.

Protein tissue specificity

Ubiquitous.

Protein sequence and domain

The leucine-zipper domain is involved in the interaction with LRPICD.Belongs to the bZIP family. Maf subfamily.; Contains 1 bZIP (basic-leucine zipper) domain.

Protein post-translational modifications

Phosphorylated by GSK3 and MAPK13 on serine and threonine residues.; Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity).

Protein cellular localization

Nucleus .

Research area

All research areas>Transcription Regulators>Maf
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize MAFB antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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