Rabbit polyclonal MAGED1 antibody (A1092)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAGED1 antibody (A1092)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MAGED1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

MAGED1 antibody,DLXIN-1 antibody,NRAGE antibody
DLXIN 1 antibody|MAGD1_HUMAN antibody|MAGE D1 antigen antibody|MAGE tumor antigen CCF antibody|MAGE-D1 antigen antibody|Maged1 antibody|Melanoma antigen family D 1 antibody|Melanoma associated antigen D1 antibody|Melanoma-associated antigen D1 antibody|Neurotrophin receptor interacting MAGE homolog antibody|Neurotrophin receptor-interacting MAGE homolog antibody|NRAGE antibody|PP2250 antibody|Anti-MAGED1 antibody (ab38492)

SCBT cat No: sc-136552|sc-136450|sc-130434|sc-393291|sc-28243|sc-398493|

Name

Rabbit polyclonal MAGED1 antibody

Catalogue No.

A1092

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAGED1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 86kDa/Observed: Refer to Figures

Formulation

MAGED1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAGED1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MAGED1 antibody,DLXIN-1 antibody,NRAGE antibody

Database links

Human UniProt/Swiss-Prot:Q9Y5V3

Protein names

MAGED1,DLXIN-1,NRAGE

Protein function

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.

Protein tissue specificity

Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.

Protein sequence and domain

Contains 1 MAGE domain.

Protein cellular localization

Cytoplasm . Cell membrane ; Peripheral membrane protein . Nucleus . Note: Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF.

Background

MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of proteins. Identified as a p75 neurotrophin receptor intracellular binding protein, MAGE-D1 induces developmental apoptosis of motoneurons, and is required for p75NTR-dependent apoptosis in sympathetic neurons. It is suggested that MAGE-D1 can suppress the motility and adhesion response of tumor cells. By forming a hetercomplex with Dlx/Msx family homeodomain proteins and Necdin, MAGE-D1 modulates the function of Dlx/Msx homeodomain during terminal differentiation and maturation of neurons. MAGE-D1 is also involved in the phosphorylation of IKK-alpha/beta, and subsequent transcriptional activation of the p65 subunit of NF-kappaB, via the XIAP-Tak1-Tab1 complex. (20100315, 19639218, 17453828, 15272023) G.

Note

AntibodyPlus can customize MAGED1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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