Rabbit polyclonal MALT1 antibody (A2144)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MALT1 antibody (A2144)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MALT1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

DKFZp434L132 antibody, MLT antibody, MLT1 antibody
Caspase like protein antibody|DKFZp434L132 antibody|MALT 1 antibody|MALT associated translocation antibody|MALT lymphoma associated translocation antibody|MALT lymphoma-associated translocation antibody|Malt1 antibody|MALT1_HUMAN antibody|MLT 1 antibody|MLT antibody|MLT1 antibody|Mucosa associated lymphoid tissue lymphoma translocation gene 1 antibody|Mucosa associated lymphoid tissue lymphoma translocation protein 1 antibody|Mucosa-associated lymphoid tissue lymphoma translocation protein 1 antibody|Paracaspase antibody|Anti-MALT1 antibody [EP603Y] (ab33921)

SCBT cat No: sc-46677|sc-20553|sc-130494|sc-515389|sc-20552|sc-28246|

Name

Rabbit polyclonal MALT1 antibody

Catalogue No.

A2144

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MALT1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 92kDa/Observed: Refer to Figures

Formulation

MALT1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MALT1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

DKFZp434L132 antibody, MLT antibody, MLT1 antibody

Database links

Human UniProt/Swiss-Prot:Q9UDY8

Protein names

DKFZp434L132, MLT, MLT1

Protein function

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.

Protein tissue specificity

Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung.

Protein sequence and domain

Belongs to the peptidase C14B family.; Contains 1 death domain.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Protein cellular localization

Cytoplasm, perinuclear region . Nucleus . Note: Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10.

Background

Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-kappaB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-kappaB, resulting in increased proliferation and inhibition of apoptosis (5,6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1 (1,2). The API2-MALT1 fusion protein likely leads to deregulation of NF-kappaB, contributing to increased oncogenic potential (7).

Research area

All research areas>Tumor Suppressor/Apoptosis>MALT1
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize MALT1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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