Rabbit polyclonal MANF antibody (A7005)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MANF antibody (A7005)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MANF antibody.

Alternative names:

Check alternative names for the antibody

Expand

ARP antibody, ARMET antibody
Arginine rich mutated in early stage tumors antibody|Arginine rich protein antibody|Arginine-rich protein antibody|ARMET antibody|ARMET protein antibody|ARP antibody|Manf antibody|MANF_HUMAN antibody|Mesencephalic astrocyte derived neurotrophic factor antibody|Mesencephalic astrocyte-derived neurotrophic factor antibody|MGC142148 antibody|MGC142150 antibody|Protein ARMET antibody|Anti-ARMET antibody (ab67271)

SCBT cat No: sc-517093|sc-34560|sc-34562|

Name

Rabbit polyclonal MANF antibody

Catalogue No.

A7005

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MANF

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 21kDa/Observed: Refer to figures

Formulation

MANF antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MANF antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

ARP antibody, ARMET antibody

Database links

Human UniProt/Swiss-Prot:P55145

Protein names

ARP, ARMET

Protein function

Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.

Protein sequence and domain

The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.Belongs to the ARMET family.

Protein post-translational modifications

May contain sialic acid residues.

Protein cellular localization

Secreted .

Background

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Research area

All research areas>Tumor Suppressor/Apoptosis>Arginine Rich Protein
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize MANF antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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