Rabbit polyclonal MAP1LC3A antibody (A5618)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAP1LC3A antibody (A5618)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MAP1LC3A antibody.

Alternative names:

Check alternative names for the antibody

Expand

LC3 antibody, LC3A antibody, ATG8E antibody, MAP1ALC3 antibody, MAP1BLC3 antibody
ATG8E antibody|LC3 antibody|LC3A antibody|MAP1 light chain 3 like protein 1 antibody|MAP1 light chain 3-like protein 1 antibody|MAP1A/1B light chain 3 A antibody|MAP1A/MAP1B LC3 A antibody|MAP1A/MAP1B light chain 3 A antibody|MAP1ALC3 antibody|MAP1BLC3 antibody|Map1lc3a antibody|Microtubule associated proteins 1A/1B light chain 3 antibody|Microtubule-associated protein 1 light chain 3 alpha antibody|Microtubule-associated proteins 1A and 1B, light chain 3 antibody|Microtubule-associated proteins 1A/1B light chain 3A antibody|MLP3A_HUMAN antibody|Anti-MAP1LC3A antibody [EP1983Y] – Autophagosome Marker (ab52768)

SCBT cat No: sc-134226|sc-16756|

Name

Rabbit polyclonal MAP1LC3A antibody

Catalogue No.

A5618

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAP1LC3A

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 14kDa/Observed: Refer to Figures

Formulation

MAP1LC3A antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAP1LC3A antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LC3 antibody, LC3A antibody, ATG8E antibody, MAP1ALC3 antibody, MAP1BLC3 antibody

Database links

Human UniProt/Swiss-Prot:Q9H492

Protein names

LC3, LC3A, ATG8E, MAP1ALC3, MAP1BLC3

Protein function

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation .

Protein tissue specificity

Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Protein sequence and domain

Belongs to the ATG8 family.

Protein post-translational modifications

The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II .; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine.; Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.

Protein cellular localization

Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome . Note: LC3-II binds to the autophagic membranes.

Background

MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis.

Note

AntibodyPlus can customize MAP1LC3A antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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