Rabbit polyclonal MAP2K4 antibody (A7724)

$69.00$259.00

Reactivity: Human
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAP2K4 antibody (A7724)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:1000 – 1:4000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MAP2K4 antibody.

Alternative names:

Check alternative names for the antibody

Expand

JNKK antibody, MEK4 antibody, MKK4 antibody, SEK1 antibody, SKK1 antibody, JNKK1 antibody, SERK1 antibody, MAPKK4 antibody, PRKMK4 antibody, SAPKK1 antibody, SAPKK-1 antibody
c Jun N terminal kinase kinase 1 antibody|C-JUN N-terminal kinase kinase 1 antibody|Dual specificity mitogen activated protein kinase kinase 4 antibody|Dual specificity mitogen-activated protein kinase kinase 4 antibody|JNK Activated Kinase 1 antibody|JNK activating kinase 1 antibody|JNK-activating kinase 1 antibody|JNKK antibody|JNKK1 antibody|MAP kinase kinase 4 antibody|Map2k4 antibody|MAPK ERK kinase 4 antibody|MAPK/ERK kinase 4 antibody|MAPKK 4 antibody|MAPKK4 antibody|MEK 4 antibody|MEK4 antibody|Mitogen activated protein kinase kinase 4 antibody|MKK 4 antibody|MKK4 antibody|MP2K4_HUMAN antibody|PRKMK4 antibody|SAPK ERK kinase 1 antibody|SAPK/ERK kinase 1 antibody|SAPKK 1 antibody|SAPKK1 antibody|SEK1 antibody|SERK1 antibody|SKK1 antibody|Stress activated protein kinase kinase 1 antibody|Phospho anti-MEK4 (S80) antibody (ab39403)

SCBT cat No: sc-136314|sc-837|sc-166168|sc-376838|sc-13070|sc-964|sc-135986|sc-1287|sc-365198|

Name

Rabbit polyclonal MAP2K4 antibody

Catalogue No.

A7724

Reactivity

Human

Immunogen

A synthetic peptide of human MAP2K4

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:1000 – 1:4000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 44kDa/Observed: Refer to figures

Formulation

MAP2K4 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAP2K4 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

JNKK antibody, MEK4 antibody, MKK4 antibody, SEK1 antibody, SKK1 antibody, JNKK1 antibody, SERK1 antibody, MAPKK4 antibody, PRKMK4 antibody, SAPKK1 antibody, SAPKK-1 antibody

Database links

Human UniProt/Swiss-Prot:P45985

Protein names

JNKK, MEK4, MKK4, SEK1, SKK1, JNKK1, SERK1, MAPKK4, PRKMK4, SAPKK1, SAPKK-1

Protein function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Protein tissue specificity

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Protein sequence and domain

The DVD domain (residues 364-387) contains a conserved docking site and is found in the mammalian MAP kinase kinases (MAP2Ks). The DVD sites bind to their specific upstream MAP kinase kinase kinases (MAP3Ks) and are essential for activation.; The D domain (residues 34-52) contains a conserved docking site and is required for the binding to MAPK substrates.Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Activated by phosphorylation on Ser-257 and Thr-261 by MAP kinase kinase kinases (MAP3Ks).

Protein cellular localization

Cytoplasm . Nucleus .

Background

This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.

Research area

All research areas>Kinases and Phosphatases>MEK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize MAP2K4 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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