Rabbit polyclonal MAP2K5 antibody (A6953)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAP2K5 antibody (A6953)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MAP2K5 antibody.

Alternative names:

Check alternative names for the antibody

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MEK5 antibody, MAPKK5 antibody, PRKMK5 antibody, HsT17454 antibody
Dual specificity mitogen activated protein kinase kinase 5 antibody|Dual specificity mitogen-activated protein kinase kinase 5 antibody|EC 2.7.12.2 antibody|HsT17454 antibody|MAP kinase kinase 5 antibody|MAP kinase kinase MEK5b antibody|MAP2K5 antibody|MAPK/ERK kinase 5 antibody|MAPKK 5 antibody|MAPKK5 antibody|MEK 5 antibody|mitogen-activated protein kinase kinase 5 antibody|MKK5 antibody|MP2K5_HUMAN antibody|PRKMK5 antibody|Protein kinase, mitogen-activated, kinase 5 antibody|SAPKK5 antibody|SKK5 antibody|Anti-MEK5 antibody (ab210748)

SCBT cat No: sc-135986|sc-1287|sc-365198|sc-10795|sc-166746|sc-166727|

Name

Rabbit polyclonal MAP2K5 antibody

Catalogue No.

A6953

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAP2K5

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 50kDa/Observed: Refer to Figures

Formulation

MAP2K5 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAP2K5 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MEK5 antibody, MAPKK5 antibody, PRKMK5 antibody, HsT17454 antibody

Database links

Human UniProt/Swiss-Prot:Q13163

Protein names

MEK5, MAPKK5, PRKMK5, HsT17454

Protein function

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Protein tissue specificity

Expressed in many adult tissues. Abundant in heart and skeletal muscle.

Protein sequence and domain

Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity).Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.; Contains 1 PB1 domain.; Contains 1 protein kinase domain.

Protein post-translational modifications

Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.; Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.

Research area

All research areas>Kinases and Phosphatases>MEK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize MAP2K5 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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