Rabbit polyclonal MAPK7 antibody (A2111)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAPK7 antibody (A2111)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

BMK1 antibody, ERK4 antibody, ERK5 antibody, PRKM7 antibody
Big MAP kinase 1 antibody|BMK 1 antibody|BMK 1 kinase antibody|BMK-1 antibody|BMK1 antibody|BMK1 Kinase antibody|EC 2.7.11.24 antibody|ERK 4 antibody|ERK 5 antibody|ERK-5 antibody|ERK4 antibody|ERK5 antibody|Extracellular signal regulated kinase 5 antibody|Extracellular signal-regulated kinase 5 antibody|MAP kinase 7 antibody|MAPK 7 antibody|MAPK7 antibody|Mitogen activated protein kinase 7 antibody|Mitogen-activated protein kinase 7 antibody|MK07_HUMAN antibody|OTTHUMP00000065906 antibody|OTTHUMP00000065907 antibody|PRKM 7 antibody|PRKM7 antibody|PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody|Anti-ERK5 antibody [EP791Y] (ab40809)

SCBT cat No: sc-81460|sc-393405|sc-1284|sc-398015|sc-5626|sc-1286|sc-293164|sc-1955|sc-100941|

Name

Rabbit polyclonal MAPK7 antibody

Catalogue No.

A2111

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAPK7

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 89kDa/Observed: Refer to Figures

Formulation

MAPK7 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAPK7 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

BMK1 antibody, ERK4 antibody, ERK5 antibody, PRKM7 antibody

Database links

Human UniProt/Swiss-Prot:Q13164

Protein names

BMK1, ERK4, ERK5, PRKM7

Protein function

Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Protein tissue specificity

Expressed in many adult tissues. Abundant in heart, placenta, lung, kidney and skeletal muscle. Not detectable in liver.

Protein sequence and domain

The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell.; The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.; Contains 1 protein kinase domain.

Protein post-translational modifications

Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme (By similarity). Autophosphorylated in vitro on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.

Protein cellular localization

Cytoplasm. Nucleus. Nucleus, PML body. Note: Translocates to the nucleus upon activation.

Background

ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation, and survival (1,5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2,3). ERK5 is also activated in response to granulocyte colony-stimulating factor (G-CSF) in hematopoetic progenitor cells where it promotes survival and proliferation (4). In neuronal cells, ERK5 is required for NGF-induced neurite outgrowth, neuronal homeostatis, and survival (11,12). ERK5 is thought to play a role in blood vessel integrity via maintainence of endothelial cell migration and barrier function (8-10). Although broadly expressed, research studies have shown that mice lacking erk5 display numerous cardiac defects, suggesting ERK5 plays a critical role in vascular development and homeostasis (1,5).

Research area

All research areas>Kinases and Phosphatases>ERK
(View all antibody categories related to Kinases and Phosphatases)

Note

AntibodyPlus can customize MAPK7 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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