Rabbit polyclonal MAPKAPK3 antibody (A7572)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

Clear
-$50 as credit for submitting review for primary antibody
Shipping notice:
Product will be delivered in 6 to 8 Business Days

Rabbit polyclonal MAPKAPK3 antibody (A7572)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MAPKAPK3 antibody.

Alternative names:

Check alternative names for the antibody

Expand

3PK antibody, MK-3 antibody, MAPKAP3 antibody, MAPKAP-K3 antibody, MAPKAPK-3 antibody
3pK antibody|anti MAPKAPK3 antibody|Chromosome 3p kinase antibody|EC 2.7.11.1 antibody|MAP kinase-activated protein kinase 3 antibody|MAPK activated protein kinase 3 antibody|MAPK-activated protein kinase 3 antibody|MAPK3_HUMAN antibody|MAPKAP antibody|MAPKAP kinase 3 antibody|MAPKAP-K3 antibody|MAPKAP3 antibody|MAPKAPK 3 antibody|MAPKAPK-3 antibody|Mapkapk3 antibody|MAPKAPK3 antibody antibody|Mitogen activated protein kinase activated protein kinase 3 antibody|Mitogen activated protein kinase activated protein kinase antibody|MK-3 antibody|Anti-MAPKAP Kinase 3 antibody (ab155178)

SCBT cat No: sc-376626|sc-376743|sc-365148|

Name

Rabbit polyclonal MAPKAPK3 antibody

Catalogue No.

A7572

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAPKAPK3

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 43kDa/Observed: Refer to figures

Formulation

MAPKAPK3 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAPKAPK3 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

3PK antibody, MK-3 antibody, MAPKAP3 antibody, MAPKAP-K3 antibody, MAPKAPK-3 antibody

Database links

Human UniProt/Swiss-Prot:Q16644

Protein names

3PK, MK-3, MAPKAP3, MAPKAP-K3, MAPKAPK-3

Protein function

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

Protein tissue specificity

Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain.

Protein sequence and domain

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.; Contains 1 protein kinase domain.

Protein post-translational modifications

Phosphorylated and activated by MAPK1/ERK2 and MAPK3/ERK1. Phosphorylated and activated by MAP kinase p38-alpha/MAPK14 at Thr-201, Ser-251 and Thr-313 (By similarity).

Protein cellular localization

Nucleus . Cytoplasm . Note: Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Background

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.

Note

AntibodyPlus can customize MAPKAPK3 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

Reviews


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review

There are no reviews for this product yet.
By submitting a review, get following benefits:

1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!

view database submit reviews

There is no extra validation for this product yet.
Check other extra validated antibodies below:



Welcome to AntibodyPlus!