Rabbit polyclonal MAVS antibody (A5764)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF,IP
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MAVS antibody (A5764)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF,IP

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:20 – 1:100 IP 1:20 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

IPS1 antibody, VISA antibody, IPS-1 antibody, CARDIF antibody
CARD adapter inducing interferon beta antibody|CARD adaptor inducing IFN beta antibody|Cardif antibody|DKFZp666M015 antibody|FLJ27482 antibody|FLJ41962 antibody|IFN B promoter stimulator 1 antibody|Interferon beta promoter stimulator protein 1 antibody|Ips 1 antibody|IPS-1 antibody|Ips1 antibody|KIAA1271 antibody|MAVS antibody|MAVS_HUMAN antibody|Mitochondrial anti viral signaling protein antibody|Mitochondrial Antiviral Signaling antibody|Mitochondrial antiviral signaling protein antibody|Mitochondrial antiviral-signaling protein antibody|Putative NF kappa B activating protein 031N antibody|Putative NF-kappa-B-activating protein 031N antibody|Virus induced signaling adapter antibody|virus induced signaling adaptor antibody|Virus-induced-signaling adapter antibody|VISA antibody|Anti-MAVS antibody – ChIP Grade (ab31334)

SCBT cat No: sc-166583|sc-365334|sc-68926|

Name

Rabbit polyclonal MAVS antibody

Catalogue No.

A5764

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MAVS

Host

Rabbit

Applications

WB, IHC, IF, IP

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:20 – 1:100
IP 1:20 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 56kDa/Observed: Refer to Figures

Formulation

MAVS antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MAVS antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

IPS1 antibody, VISA antibody, IPS-1 antibody, CARDIF antibody

Database links

Human UniProt/Swiss-Prot:Q7Z434

Protein names

IPS1, VISA, IPS-1, CARDIF

Protein function

Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.

Protein tissue specificity

Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes.

Protein sequence and domain

Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58/RIG-I and IFIH1/MDA5.; The transmembrane domain and residues 300-444 are essential for its interaction with DHX58/LGP2.Contains 1 CARD domain.

Protein post-translational modifications

Ubiquitinated; undergoes ‘Lys-48’-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS/IPS1 proteasomal degradation.

Protein cellular localization

Mitochondrion outer membrane. Mitochondrion. Peroxisome.

Background

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.

Note

AntibodyPlus can customize MAVS antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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