Rabbit polyclonal MB21D1 antibody (A8335)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MB21D1 antibody (A8335)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MB21D1 antibody.

Alternative names:

Check alternative names for the antibody

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cGAS antibody, h-cGAS antibody, C6orf150 antibody
C6orf150 antibody|cGAMP synthase antibody|cGAS antibody|CGAS_HUMAN antibody|cGMP Synthase antibody|Chromosome 6 open reading frame 150 antibody|Cyclic GMP-AMP synthase antibody|h-cGAS antibody|Hypothetical protein LOC115004 antibody|Mab 21 domain containing 1 antibody|Mab-21 domain-containing protein 1 antibody|MB21D1 antibody|MGC131892 antibody|MGC142166 antibody|MGC142168 antibody|OTTHUMP00000016743 antibody|OTTHUMP00000039330 antibody|protein MB21D1 antibody|Uncharacterized protein C6orf150 antibody|Anti-C6orf150 antibody (ab176177)

SCBT cat No: sc-245858|

Name

Rabbit polyclonal MB21D1 antibody

Catalogue No.

A8335

Reactivity

Human, Mouse

Immunogen

A synthetic peptide of human MB21D1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 59kDa/Observed: Refer to Figures

Formulation

MB21D1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MB21D1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

cGAS antibody, h-cGAS antibody, C6orf150 antibody

Database links

Human UniProt/Swiss-Prot:Q8N884

Protein names

cGAS, h-cGAS, C6orf150

Protein function

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2′,5′ phosphodiester linkage at the GpA step and the formation of a 3′,5′ phosphodiester linkage at the ApG step, producing c[G(2′,5′)pA(3′,5′)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner .

Protein tissue specificity

Expressed in the monocytic cell line THP1.

Protein sequence and domain

Belongs to the mab-21 family.

Protein post-translational modifications

Polyglutamylated by TTLL6 at Glu-286, leading to impair DNA-binding activity. Monoglutamylated at Glu-314 by TTLL4, leading to impair the nucleotidyltransferase activity. Deglutamylated by AGBL5/CCP5 and AGBL6/CCP6.

Protein cellular localization

Cytoplasm, cytosol .

Note

AntibodyPlus can customize MB21D1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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