Rabbit polyclonal MBNL1 antibody (A8054)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MBNL1 antibody (A8054)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MBNL1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

EXP antibody, MBNL antibody, EXP35 antibody, EXP40 antibody, EXP42 antibody
EXP antibody|EXP35 antibody|EXP40 antibody|EXP42 antibody|KIAA0428 antibody|MBNL antibody|MBNL protein antibody|MBNL1 antibody|MBNL1_HUMAN antibody|Muscleblind 41kD isoform antibody|Muscleblind like antibody|Muscleblind like protein 1 antibody|Muscleblind like splicing regulator 1 antibody|Muscleblind-like protein 1 antibody|Triplet expansion RNA binding protein antibody|Triplet-expansion RNA-binding protein antibody|Anti-Muscleblind-like 1 antibody (ab45899)

SCBT cat No: sc-47740|sc-136165|sc-50087|sc-136166|sc-515374|sc-58790|sc-50088|

Name

Rabbit polyclonal MBNL1 antibody

Catalogue No.

A8054

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MBNL1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 42kDa/Observed: Refer to figures

Formulation

MBNL1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MBNL1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EXP antibody, MBNL antibody, EXP35 antibody, EXP40 antibody, EXP42 antibody

Database links

Human UniProt/Swiss-Prot:Q9NR56

Protein names

EXP, MBNL, EXP35, EXP40, EXP42

Protein function

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5′-YGCU(U/G)Y-3’consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.

Protein tissue specificity

Highly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Protein sequence and domain

Belongs to the muscleblind family.; Contains 4 C3H1-type zinc fingers.

Protein cellular localization

Nucleus . Cytoplasm . Cytoplasmic granule . Note: Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress . Localized in the cytoplasm of multinucleated myotubes . Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy .

Note

AntibodyPlus can customize MBNL1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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