Rabbit polyclonal MBTPS1 antibody (A7025)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MBTPS1 antibody (A7025)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MBTPS1 antibody.

Alternative names:

Check alternative names for the antibody

Expand

S1P antibody, PCSK8 antibody, SKI-1 antibody
kexin isozyme 1 antibody|KIAA0091 antibody|MBTPS1 antibody|membrane bound transcription factor peptidase, site 1 antibody|MGC138711 antibody|MGC138712 antibody|PCSK8 antibody|S1P antibody|S1P endopeptidase antibody|Site 1 protease antibody|SKI 1 antibody|SKI1 antibody|Subtilisin isozyme 1 antibody|Subtilisin/kexin isozyme 1 antibody|Anti-S1P antibody (ab140592)

SCBT cat No:

Name

Rabbit polyclonal MBTPS1 antibody

Catalogue No.

A7025

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MBTPS1

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 118kDa/Observed: Refer to figures

Formulation

MBTPS1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MBTPS1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

S1P antibody, PCSK8 antibody, SKI-1 antibody

Database links

Human UniProt/Swiss-Prot:Q14703

Protein names

S1P, PCSK8, SKI-1

Protein function

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Protein tissue specificity

Widely expressed.

Protein sequence and domain

Belongs to the peptidase S8 family.; Contains 1 peptidase S8 domain.

Protein post-translational modifications

The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates.

Protein cellular localization

Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Note: May sort to other organelles, including lysosomal and/or endosomal compartments.

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction.

Research area

All research areas>Synthesis and Degradation>SKI-1
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize MBTPS1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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