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Rabbit polyclonal MBTPS1 antibody (A7025)
$69.00–$259.00
Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.
Rabbit polyclonal MBTPS1 antibody (A7025)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
Recommended dilution:
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100
Recommended protocols: check protocols
Image descriptions:
Click or hover above images to see image description for Rabbit polyclonal MBTPS1 antibody.
Alternative names:
Check alternative names for the antibody
ExpandS1P antibody, PCSK8 antibody, SKI-1 antibody
kexin isozyme 1 antibody|KIAA0091 antibody|MBTPS1 antibody|membrane bound transcription factor peptidase, site 1 antibody|MGC138711 antibody|MGC138712 antibody|PCSK8 antibody|S1P antibody|S1P endopeptidase antibody|Site 1 protease antibody|SKI 1 antibody|SKI1 antibody|Subtilisin isozyme 1 antibody|Subtilisin/kexin isozyme 1 antibody|Anti-S1P antibody (ab140592)
SCBT cat No:
| Name | Rabbit polyclonal MBTPS1 antibody |
|---|---|
| Catalogue No. | A7025 |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Recombinant protein of human MBTPS1 |
| Host | Rabbit |
| Applications | WB, IHC, IF |
| Recommended dilution | WB 1:500 – 1:2000 |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Molecular weight | Predicted: 118kDa/Observed: Refer to figures |
| Formulation | MBTPS1 antibody was tube-contained. |
| Purification | MBTPS1 antibody was purified using affinity purification. |
| Storage | Store at -20 Celsius degree. Avoid freeze / thaw cycles. |
| Alternative antibody names | S1P antibody, PCSK8 antibody, SKI-1 antibody |
| Database links | Human UniProt/Swiss-Prot:Q14703 |
| Protein names | S1P, PCSK8, SKI-1 |
| Protein function | Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes. |
| Protein tissue specificity | Widely expressed. |
| Protein sequence and domain | Belongs to the peptidase S8 family.; Contains 1 peptidase S8 domain. |
| Protein post-translational modifications | The 148 kDa zymogen is processed progressively into two membrane-bound 120 and 106 kDa forms in the endoplasmic reticulum, and late into a secreted 98 kDa form. The propeptide is autocatalytically removed through an intramolecular cleavage after Leu-186. Further cleavage generates 14, 10, and 8 kDa intermediates. |
| Protein cellular localization | Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Note: May sort to other organelles, including lysosomal and/or endosomal compartments. |
| Background | This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues. Mutations in this gene may be associated with lysosomal dysfunction. |
| Research area | All research areas>Synthesis and Degradation>SKI-1 |
| Note | AntibodyPlus can customize MBTPS1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation. |
| Product type | Primary antibody |
| Supplier | ABclonal Inc. |
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