Rabbit polyclonal MCM10 antibody (A7199)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MCM10 antibody (A7199)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MCM10 antibody.

Alternative names:

Check alternative names for the antibody

Expand

CNA43 antibody, DNA43 antibody, PRO2249 antibody
FLJ31133 antibody|HsMCM10 antibody|mcm10 antibody|MCM10 minichromosome maintenance deficient 10 antibody|MCM10_HUMAN antibody|Minichromosome maintenance protein 10 isoform 1 antibody|PRO2249 antibody|Protein MCM10 homolog antibody|Anti-MCM10 antibody (ab3733)

SCBT cat No: sc-47111|

Name

Rabbit polyclonal MCM10 antibody

Catalogue No.

A7199

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MCM10

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 98kDa/Observed: Refer to figures

Formulation

MCM10 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MCM10 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

CNA43 antibody, DNA43 antibody, PRO2249 antibody

Database links

Human UniProt/Swiss-Prot:Q7L590

Protein names

CNA43, DNA43, PRO2249

Protein function

Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 .

Protein sequence and domain

Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain.; The N-terminal domain mediates homodimerization.Belongs to the MCM10 family.

Protein cellular localization

Nucleus . Note: Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli.

Background

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Research area

All research areas>Cell Cycle Proteins>MCM
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize MCM10 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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