Rabbit polyclonal MDK antibody (A0251)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MDK antibody (A0251)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MDK antibody,FLJ27379 antibody,MK antibody,NEGF2 antibody
Amphiregulin associated protein antibody|Amphiregulin-associated protein antibody|ARAP antibody|FLJ27379 antibody|Mdk antibody|Midgestation and kidney protein antibody|Midkine antibody|MK 1 antibody|MK antibody|MK_HUMAN antibody|MK1 antibody|NEGF 2 antibody|NEGF2 antibody|Neurite growth promoting factor 2 antibody|Neurite outgrowth promoting protein antibody|Neurite outgrowth-promoting factor 2 antibody|Neurite outgrowth-promoting protein antibody|Retinoic acid inducible factor antibody|Anti-Midkine antibody [EP1143Y] (ab52637)

SCBT cat No: sc-46701|sc-20715|sc-1398|

Name

Rabbit polyclonal MDK antibody

Catalogue No.

A0251

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MDK

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 16kDa/Observed: Refer to Figures

Formulation

MDK antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MDK antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MDK antibody,FLJ27379 antibody,MK antibody,NEGF2 antibody

Database links

Human UniProt/Swiss-Prot:P21741

Protein names

MDK,FLJ27379,MK,NEGF2

Protein function

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).

Protein tissue specificity

Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions.

Protein sequence and domain

Belongs to the pleiotrophin family.

Protein cellular localization

Secreted.

Background

Midkine, or MK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MK functions to enhance the activity of plasminogen activator (PA).

Research area

All research areas>Growth Factors and Hormones>MK
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize MDK antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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