Rabbit polyclonal MECOM antibody (A5674)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MECOM antibody (A5674)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

Click or hover above images to see image description for Rabbit polyclonal MECOM antibody.

Alternative names:

Check alternative names for the antibody

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EVI1 antibody, MDS1 antibody, PRDM3 antibody, MDS1-EVI1 antibody, AML1-EVI-1 antibody
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SCBT cat No:

Name

Rabbit polyclonal MECOM antibody

Catalogue No.

A5674

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MECOM

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 18kDa/Observed: Refer to Figures

Formulation

MECOM antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MECOM antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

EVI1 antibody, MDS1 antibody, PRDM3 antibody, MDS1-EVI1 antibody, AML1-EVI-1 antibody

Database links

Human UniProt/Swiss-Prot:Q03112

Protein names

EVI1, MDS1, PRDM3, MDS1-EVI1, AML1-EVI-1

Protein function

Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.

Protein sequence and domain

Both zinc finger regions are required for the transcriptional activation of PBX1.Contains 10 C2H2-type zinc fingers.

Protein post-translational modifications

Phosphorylated.; May be acetylated by CREBBP and KAT2B.

Protein cellular localization

Nucleus. Nucleus speckle.

Background

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Note

AntibodyPlus can customize MECOM antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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