Rabbit polyclonal MECP2 antibody (A5694)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MECP2 antibody (A5694)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:100 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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RS antibody, RTS antibody, RTT antibody, PPMX antibody, MRX16 antibody, MRX79 antibody, MRXSL antibody, AUTSX3 antibody, MRXS13 antibody
AUTSX 3 antibody|AUTSX3 antibody|DKFZp686A24160 antibody|Mbd 5 antibody|Mbd5 antibody|MECP 2 antibody|MeCP 2 protein antibody|MeCP-2 protein antibody|Mecp2 antibody|MECP2_HUMAN antibody|Methyl CpG binding protein 2 (Rett syndrome) antibody|Methyl CpG binding protein 2 antibody|Methyl-CpG-binding protein 2 antibody|MRX 16 antibody|MRX 79 antibody|MRX16 antibody|MRX79 antibody|MRXS 13 antibody|MRXS13 antibody|MRXSL antibody|PPMX antibody|RS antibody|RTS antibody|RTT antibody|WBP 10 antibody|WBP10 antibody|Anti-MeCP2 antibody – ChIP Grade (ab2828)

SCBT cat No: sc-5758|sc-137071|sc-137070|sc-20700|sc-5755|sc-393450|

Name

Rabbit polyclonal MECP2 antibody

Catalogue No.

A5694

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human MECP2

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:100 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to Figures

Formulation

MECP2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MECP2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

RS antibody, RTS antibody, RTT antibody, PPMX antibody, MRX16 antibody, MRX79 antibody, MRXSL antibody, AUTSX3 antibody, MRXS13 antibody

Database links

Human UniProt/Swiss-Prot:P51608

Protein names

RS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13

Protein function

Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).

Protein tissue specificity

Present in all adult somatic tissues tested.

Protein sequence and domain

Contains 2 A.T hook DNA-binding domains.; Contains 1 MBD (methyl-CpG-binding) domain.

Protein post-translational modifications

Phosphorylated on Ser-423 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation.

Protein cellular localization

Nucleus. Note: Colocalized with methyl-CpG in the genome.

Background

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Research area

All research areas>Transcription Regulators>MeCP2
(View all antibody categories related to Transcription Regulators)

Note

AntibodyPlus can customize MECP2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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