Rabbit polyclonal MEIS2 antibody (A8437)

$69.00$259.00

Reactivity: Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MEIS2 antibody (A8437)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MRG1 antibody, HsT18361 antibody
Homeobox protein Meis2 antibody|MEIS2 antibody|MEIS2_HUMAN antibody|MGC2820 antibody|MRG1 antibody|TALE homeobox protein Meis2 antibody|Anti-MEIS2 antibody (ab73164)

SCBT cat No: sc-515470|sc-374654|sc-84112|

Name

Rabbit polyclonal MEIS2 antibody

Catalogue No.

A8437

Reactivity

Mouse, Rat

Immunogen

Recombinant protein of human MEIS2

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 52kDa/Observed: Refer to figures

Formulation

MEIS2 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MEIS2 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MRG1 antibody, HsT18361 antibody

Database links

Human UniProt/Swiss-Prot:O14770

Protein names

MRG1, HsT18361

Protein function

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5′-CGGTCA-3′; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5′-TGACAG-3’in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.

Protein tissue specificity

Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.

Protein sequence and domain

Belongs to the TALE/MEIS homeobox family.; Contains 1 homeobox DNA-binding domain.

Protein cellular localization

Nucleus . Cytoplasm, perinuclear region .

Background

This gene encodes a homeobox protein belonging to the TALE (‘three amino acid loop extension’) family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Note

AntibodyPlus can customize MEIS2 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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