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Rabbit polyclonal MFN1 antibody (A9880)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal MFN1 antibody.
Check alternative names for the antibodyExpand
Fzo homolog antibody|Hfzo1 antibody|Hfzo2 antibody|MFN 1 antibody|Mfn1 antibody|MFN1_HUMAN antibody|Mitochondrial transmembrane GTPase Fzo 1 antibody|Mitochondrial transmembrane GTPase FZO 2 antibody|Mitochondrial transmembrane GTPase FZO1B antibody|Mitofusin 1 antibody|Mitofusin-1 antibody|Mitofusin1 antibody|MS996 antibody|Putative transmembrane GTPase antibody|Transmembrane GTPase MFN1 antibody|Anti-Mitofusin 1 antibody (ab57602)
SCBT cat No: sc-166644|sc-50330|sc-30363|
Rabbit polyclonal MFN1 antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human MFN1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 84kDa/Observed: Refer to figures
MFN1 antibody was tube-contained.
MFN1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.
|Protein tissue specificity|| |
Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.
|Protein sequence and domain|| |
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.; Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
|Protein post-translational modifications|| |
Ubiquitinated by non-degradative ubiquitin by PARK2, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion (By similarity). Ubiquitinated by MARCH5. When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PARK2.
|Protein cellular localization|| |
Mitochondrion outer membrane ; Multi-pass membrane protein .; Isoform 2: Cytoplasm.
AntibodyPlus can customize MFN1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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