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Rabbit polyclonal MGMT antibody (A0693)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC,IF
WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200
Recommended protocols: check protocols
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Check alternative names for the antibodyExpand
6 O methylguanine DNA methyltransferase antibody|6-O-methylguanine-DNA methyltransferase antibody|Agat antibody|AGT antibody|AI267024 antibody|EC 18.104.22.168 antibody|Methylated DNA protein cysteine methyltransferase antibody|Methylated-DNA–protein-cysteine methyltransferase antibody|Methylguanine DNA methyltransferase antibody|MGC107020 antibody|MGMT antibody|MGMT_HUMAN antibody|O 6 methylguanine DNA alkyltransferase antibody|O 6 methylguanine DNA methyltransferase antibody|O-6-methylguanine-DNA methyltransferase antibody|O-6-methylguanine-DNA-alkyltransferase antibody|Anti-MGMT antibody [MT3.1] (ab39253)
SCBT cat No: sc-8825|sc-271154|sc-166527|sc-166528|sc-166491|sc-271155|sc-28241|sc-514277|sc-56157|sc-33674|sc-8824|sc-56432|
Rabbit polyclonal MGMT antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human MGMT
WB, IHC, IF
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 22kDa/Observed: Refer to Figures
MGMT antibody was tube-contained.
MGMT antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
|Protein names|| |
|Protein function|| |
Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
|Protein sequence and domain|| |
Belongs to the MGMT family.
|Protein cellular localization|| |
MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O(6) position of guanine, restoring guanine to its normal form without causing DNA breaks (1). MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents (2,3). It is ubiquitously expressed in normal human tissues (4) and is overexpressed in many types of human tumors, but epigenetically silenced in other tumors. MGMT silencing is a marker associated with poor prognosis, but is a good predictive marker for response to alkylating agent chemotherapy (5).
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|Product type|| |
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