Rabbit polyclonal MGMT antibody (A0693)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MGMT antibody (A0693)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC,IF

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200 IF 1:50 – 1:200

Recommended protocols: check protocols

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Alternative names:

Check alternative names for the antibody

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MGMT antibody
6 O methylguanine DNA methyltransferase antibody|6-O-methylguanine-DNA methyltransferase antibody|Agat antibody|AGT antibody|AI267024 antibody|EC 2.1.1.63 antibody|Methylated DNA protein cysteine methyltransferase antibody|Methylated-DNA–protein-cysteine methyltransferase antibody|Methylguanine DNA methyltransferase antibody|MGC107020 antibody|MGMT antibody|MGMT_HUMAN antibody|O 6 methylguanine DNA alkyltransferase antibody|O 6 methylguanine DNA methyltransferase antibody|O-6-methylguanine-DNA methyltransferase antibody|O-6-methylguanine-DNA-alkyltransferase antibody|Anti-MGMT antibody [MT3.1] (ab39253)

SCBT cat No: sc-8825|sc-271154|sc-166527|sc-166528|sc-166491|sc-271155|sc-28241|sc-514277|sc-56157|sc-33674|sc-8824|sc-56432|

Name

Rabbit polyclonal MGMT antibody

Catalogue No.

A0693

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MGMT

Host

Rabbit

Applications

WB, IHC, IF

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 22kDa/Observed: Refer to Figures

Formulation

MGMT antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MGMT antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MGMT antibody

Database links

Human UniProt/Swiss-Prot:P16455

Protein names

MGMT

Protein function

Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

Protein sequence and domain

Belongs to the MGMT family.

Protein cellular localization

Nucleus.

Background

MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O(6) position of guanine, restoring guanine to its normal form without causing DNA breaks (1). MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents (2,3). It is ubiquitously expressed in normal human tissues (4) and is overexpressed in many types of human tumors, but epigenetically silenced in other tumors. MGMT silencing is a marker associated with poor prognosis, but is a good predictive marker for response to alkylating agent chemotherapy (5).

Research area

All research areas>Tumor Suppressor/Apoptosis>MGMT
(View all antibody categories related to Tumor Suppressor/Apoptosis)

Note

AntibodyPlus can customize MGMT antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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