No products in the cart.
Rabbit polyclonal MIB1 antibody (A8588)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit polyclonal MIB1 antibody.
Check alternative names for the antibodyExpand
DAPK-interacting protein 1 antibody|Dip 1 antibody|DIP-1 antibody|Dip1 antibody|E3 ubiquitin protein ligase MIB 1 antibody|E3 ubiquitin protein ligase MIB1 antibody|E3 ubiquitin-protein ligase mib1 antibody|KIAA1323 antibody|LVNC7 antibody|MIB antibody|mib1 antibody|MIB1_HUMAN antibody|Mind bomb homolog 1 antibody|Mindbomb E3 ubiquitin protein ligase 1 antibody|Ubiquitin ligase mind bomb antibody|Zinc finger ZZ type with ankyrin repeat domain protein 2 antibody|ZZANK2 antibody|ZZZ6 antibody|Anti-Mib1/Mindbomb antibody [EPR2762(2)] (ab124929)
SCBT cat No: sc-393811|sc-85059|sc-393551|sc-368128|sc-85061|
Rabbit polyclonal MIB1 antibody
|Catalogue No.|| |
Recombinant protein of human MIB1
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
Predicted: 110kDa/Observed: Refer to figures
MIB1 antibody was tube-contained.
MIB1 antibody was purified using affinity purification.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Database links|| |
|Protein function|| |
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates ‘Lys-63’-linked polyubiquitination of TBK1, which probably participates in kinase activation.
|Protein tissue specificity|| |
Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.
|Protein sequence and domain|| |
Contains 9 ANK repeats.; Contains 2 MIB/HERC2 domains.; Contains 3 RING-type zinc fingers.; Contains 1 ZZ-type zinc finger.
|Protein post-translational modifications|| |
Ubiquitinated; possibly via autoubiquitination (By similarity). Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
|Protein cellular localization|| |
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cell membrane . Note: Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]
AntibodyPlus can customize MIB1 antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
There are no reviews for this product yet.
By submitting a review, get following benefits:
1. Receive $50 ABcoins as credit for each review.
2. First trial sample order will be fully refunded as credit.
3. Have a chance to win a $50 amazon gift card!
There is no extra validation for this product yet.
Check other extra validated antibodies below: