Rabbit polyclonal MIB1 antibody (A8588)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MIB1 antibody (A8588)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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DAPK-interacting protein 1 antibody|Dip 1 antibody|DIP-1 antibody|Dip1 antibody|E3 ubiquitin protein ligase MIB 1 antibody|E3 ubiquitin protein ligase MIB1 antibody|E3 ubiquitin-protein ligase mib1 antibody|KIAA1323 antibody|LVNC7 antibody|MIB antibody|mib1 antibody|MIB1_HUMAN antibody|Mind bomb homolog 1 antibody|Mindbomb E3 ubiquitin protein ligase 1 antibody|Ubiquitin ligase mind bomb antibody|Zinc finger ZZ type with ankyrin repeat domain protein 2 antibody|ZZANK2 antibody|ZZZ6 antibody|Anti-Mib1/Mindbomb antibody [EPR2762(2)] (ab124929)

SCBT cat No: sc-393811|sc-85059|sc-393551|sc-368128|sc-85061|

Name

Rabbit polyclonal MIB1 antibody

Catalogue No.

A8588

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human MIB1

Host

Rabbit

Applications

WB

Recommended dilution

WB 1:500 – 1:2000

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 110kDa/Observed: Refer to figures

Formulation

MIB1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MIB1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:Q86YT6

Protein function

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates ‘Lys-63’-linked polyubiquitination of TBK1, which probably participates in kinase activation.

Protein tissue specificity

Widely expressed at low level. Expressed at higher level in spinal cord, ovary, whole brain, and all specific brain regions examined.

Protein sequence and domain

Contains 9 ANK repeats.; Contains 2 MIB/HERC2 domains.; Contains 3 RING-type zinc fingers.; Contains 1 ZZ-type zinc finger.

Protein post-translational modifications

Ubiquitinated; possibly via autoubiquitination (By similarity). Ubiquitinated; this modification is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.

Protein cellular localization

Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cell membrane . Note: Localizes to the plasma membrane (By similarity). According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock.

Background

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

Research area

All research areas>Growth Factors and Hormones>MIB1
(View all antibody categories related to Growth Factors and Hormones)

Note

AntibodyPlus can customize MIB1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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