Rabbit polyclonal MIP antibody (A2886)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MIP antibody (A2886)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:1000 IHC 1:100 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

LIM1 antibody,MP26 antibody,MIP26 antibody,MIP antibody
AQP 0 antibody|AQP0 antibody|Aquaporin antibody|Aquaporin-0 antibody|Aquaporin0 antibody|Lens fiber major intrinsic protein antibody|LIM 1 antibody|LIM1 antibody|Major intrinsic protein 26kD antibody|Major intrinsic protein of lens fiber antibody|MIP 26 antibody|mip antibody|MIP_HUMAN antibody|MIP26 antibody|MP 26 antibody|MP26 antibody|PALM antibody|Anti-Aquaporin 0 antibody (ab134695)

SCBT cat No: sc-376445|sc-99059|sc-49364|

Name

Rabbit polyclonal MIP antibody

Catalogue No.

A2886

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide of human MIP

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:1000
IHC 1:100 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 28kDa/Observed: Refer to Figures

Formulation

MIP antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MIP antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

LIM1 antibody,MP26 antibody,MIP26 antibody,MIP antibody

Database links

Human UniProt/Swiss-Prot:P30301

Protein names

LIM1,MP26,MIP26,MIP

Protein function

Water channel . Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling .

Protein tissue specificity

Major component of lens fiber gap junctions.

Protein sequence and domain

Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side (By similarity).Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein post-translational modifications

Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes (By similarity).

Protein cellular localization

Cell membrane ; Multi-pass membrane protein . Cell junction, gap junction .

Background

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.

Research area

All research areas>Channel Proteins>AQP
(View all antibody categories related to Channel Proteins)

Note

AntibodyPlus can customize MIP antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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