Rabbit polyclonal MKI67 antibody (A2094)

$69.00$259.00

Reactivity: Human
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MKI67 antibody (A2094)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

Expand

KIA antibody, MIB antibody, MIB-1 antibody, PPP1R105 antibody
Antigen identified by monoclonal antibody Ki 67 antibody|Protein phosphatase 1 regulatory subunit 105 antibody|RP11-380J17.2 antibody|Anti-Ki67 antibody (ab15580)

SCBT cat No: sc-7844|sc-15402|sc-23900|sc-7846|sc-56319|sc-101861|

Name

Rabbit polyclonal MKI67 antibody

Catalogue No.

A2094

Reactivity

Human

Immunogen

Recombinant protein of human MKI67

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 359kDa/Observed: Refer to Figures

Formulation

MKI67 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MKI67 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

KIA antibody, MIB antibody, MIB-1 antibody, PPP1R105 antibody

Database links

Human UniProt/Swiss-Prot:P46013

Protein names

KIA, MIB, MIB-1, PPP1R105

Protein function

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly . Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface . Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility . Binds DNA, with a preference for supercoiled DNA and AT-rich DNA . Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization . It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Protein sequence and domain

Contains 1 FHA domain.; Contains 16 K167R repeats.; Contains 1 PP1-binding domain.

Protein post-translational modifications

Phosphorylated. Hyperphosphorylated in mitosis . Hyperphosphorylated form does not bind DNA.

Protein cellular localization

Chromosome . Nucleus . Nucleus, nucleolus . Note: Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the mitotic chromosome surface . Associates with satellite DNA in G1 phase . Binds tightly to chromatin in interphase, chromatin-binding decreases in mitosis when it associates with the surface of the condensed chromosomes . Predominantly localized in the G1 phase in the perinucleolar region, in the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix .

Background

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X.

Research area

All research areas>Cell Cycle Proteins>Ki-67
(View all antibody categories related to Cell Cycle Proteins)

Note

AntibodyPlus can customize MKI67 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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