Rabbit polyclonal MLF1 antibody (A8012)

$69.00$259.00

Reactivity: Human
Applications: WB,IF
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MLF1 antibody (A8012)

Supplier: ABclonal Inc.

Recommended applications: WB,IF

Recommended dilution:

WB 1:500 – 1:2000 IF 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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Hls7 antibody|MLF1 antibody|MLF1_HUMAN antibody|Myelodysplasia myeloid leukemia factor 1 antibody|Myelodysplasia-myeloid leukemia factor 1 antibody|Myeloid leukemia factor 1 antibody|myeloid leukemia factor 1 variant 1 antibody|myeloid leukemia factor 1 variant 2 antibody|myeloid leukemia factor 1 variant 3 antibody|Anti-Myeloid leukemia factor 1 antibody (ab103099)

SCBT cat No: sc-514304|sc-514294|sc-134895|

Name

Rabbit polyclonal MLF1 antibody

Catalogue No.

A8012

Reactivity

Human

Immunogen

Recombinant protein of human MLF1

Host

Rabbit

Applications

WB, IF

Recommended dilution

WB 1:500 – 1:2000
IF 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 31kDa/Observed: Refer to figures

Formulation

MLF1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MLF1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Database links

Human UniProt/Swiss-Prot:P58340

Protein function

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Protein tissue specificity

Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.

Protein sequence and domain

Belongs to the MLF family.

Protein post-translational modifications

Phosphorylation is required for binding to YWHAZ.

Protein cellular localization

Cytoplasm . Nucleus . Note: Shuttles between the cytoplasm and nucleus.

Background

This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.

Research area

All research areas>Signaling Intermediates>MLF
(View all antibody categories related to Signaling Intermediates)

Note

AntibodyPlus can customize MLF1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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