Rabbit Polyclonal MMACHC antibody (A10355)

$99.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit Polyclonal MMACHC antibody (A10355)

Supplier: ABclonal Inc.

Recommended applications: WB

Recommended dilution:

WB 1:500 – 1:2000

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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cblC antibody;
1810037K07Rik antibody|BOS_3654 antibody|cblC antibody|DKFZp564I122 antibody|FLJ25671 antibody|Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria antibody|Methylmalonic aciduria and homocystinuria type C protein antibody|Methylmalonic aciduria and homocystinuria type C protein homolog antibody|MGC134307 antibody|MMAC_HUMAN antibody|MMACHC antibody|OTTHUMP00000009243 antibody|RP11 291L19.3 antibody|RP23-177C18.3 antibody|Anti-MMACHC antibody (ab187737)

SCBT cat No: sc-161861|sc-161862|

Name

Rabbit Polyclonal MMACHC antibody

Catalogue No.

A10355

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MMACHC

Host

Rabbit

Applications

WB

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

31kDa

Formulation

MMACHC antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

Affinity purification

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

cblC antibody;

Protein names

cblC;

Protein function

Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810). Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485). Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen (PubMed:19801555). Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).

Protein tissue specificity

Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.

Protein sequence and domain

Belongs to the MMACHC family.

Protein cellular localization

Cytoplasm .

Background

The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.

Note

AntibodyPlus can customize MMACHC antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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