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Rabbit Polyclonal MMACHC antibody (A10355)
Supplier: ABclonal Inc.
Recommended applications: WB
WB 1:500 – 1:2000
Recommended protocols: check protocols
Click or hover above images to see image description for Rabbit Polyclonal MMACHC antibody.
Check alternative names for the antibodyExpand
1810037K07Rik antibody|BOS_3654 antibody|cblC antibody|DKFZp564I122 antibody|FLJ25671 antibody|Methylmalonic aciduria (cobalamin deficiency) cblC type with homocystinuria antibody|Methylmalonic aciduria and homocystinuria type C protein antibody|Methylmalonic aciduria and homocystinuria type C protein homolog antibody|MGC134307 antibody|MMAC_HUMAN antibody|MMACHC antibody|OTTHUMP00000009243 antibody|RP11 291L19.3 antibody|RP23-177C18.3 antibody|Anti-MMACHC antibody (ab187737)
SCBT cat No: sc-161861|sc-161862|
Rabbit Polyclonal MMACHC antibody
|Catalogue No.|| |
Human, Mouse, Rat
Recombinant protein of human MMACHC
|Recommended dilution|| |
WB 1:500 – 1:2000
|Molecular weight|| |
MMACHC antibody was tube-contained.
Store at -20 Celsius degree. Avoid freeze / thaw cycles.
|Alternative antibody names|| |
|Database links|| |
Human UniProt/Swiss-Prot:<a href="http://www.uniprot.org/uniprot/Q9Y4U1">Q9Y4U1</a>
|Protein names|| |
|Protein function|| |
Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810). Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485). Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen (PubMed:19801555). Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).
|Protein tissue specificity|| |
Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.
|Protein sequence and domain|| |
Belongs to the MMACHC family.
|Protein cellular localization|| |
The exact function of the protein encoded by this gene is not known, however, its C-terminal region shows similarity to TonB, a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Hence, it is postulated that this protein may have a role in the binding and intracellular trafficking of cobalamin. Mutations in this gene are associated with methylmalonic aciduria and homocystinuria type cblC.
AntibodyPlus can customize MMACHC antibody according to your requirement, including bulk product size,etc. Please contact email@example.com. AntibodyPlus provides antibody trial sample for your own antibody validation.
|Product type|| |
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