Rabbit polyclonal MMP1 antibody (A1191)

$69.00$259.00

Reactivity: Human,Mouse
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MMP1 antibody (A1191)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:200

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MMP1 antibody,CLG antibody,CLGN antibody
27 kDa interstitial collagenase antibody|CLG antibody|CLGN antibody|collagenase, fibroblast antibody|collagenase, interstitial antibody|Fibroblast collagenase antibody|Interstitial collagenase antibody|Matrix metallopeptidase 1 (interstitial collagenase) antibody|Matrix metalloprotease 1 antibody|Matrix Metalloproteinase 1 antibody|Matrix metalloproteinase-1 antibody|MMP 1 antibody|MMP-1 antibody|MMP1 antibody|MMP1_HUMAN antibody|OTTHUMP00000045866 antibody|Anti-MMP1 antibody [EP1247Y] (ab52631)

SCBT cat No: sc-21731|sc-6837|sc-12348|sc-8834|sc-58377|sc-137044|sc-30069|

Name

Rabbit polyclonal MMP1 antibody

Catalogue No.

A1191

Reactivity

Human, Mouse

Immunogen

Recombinant protein of human MMP1

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:200

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 54kDa/Observed: Refer to Figures

Formulation

MMP1 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MMP1 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MMP1 antibody,CLG antibody,CLGN antibody

Database links

Human UniProt/Swiss-Prot:P03956

Protein names

MMP1,CLG,CLGN

Protein function

Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity.

Protein sequence and domain

There are two distinct domains in this protein; the catalytic N-terminal, and the C-terminal which is involved in substrate specificity and in binding TIMP (tissue inhibitor of metalloproteinases).; The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.Belongs to the peptidase M10A family.; Contains 4 hemopexin repeats.

Protein post-translational modifications

Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase.; Tyrosine phosphorylated in platelets by PKDCC/VLK.

Protein cellular localization

Secreted, extracellular space, extracellular matrix .

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Research area

All research areas>Synthesis and Degradation>MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize MMP1 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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