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Rabbit polyclonal MMP14 antibody (A2549)
$69.00–$259.00
Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.
Rabbit polyclonal MMP14 antibody (A2549)
Supplier: ABclonal Inc.
Recommended applications: WB,IHC
Recommended dilution:
WB 1:500 – 1:2000 IHC 1:50 – 1:100
Recommended protocols: check protocols
Image descriptions:
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Alternative names:
Check alternative names for the antibody
ExpandMMP-14 antibody, MMP-X1 antibody, MT-MMP antibody, MT1MMP antibody, MTMMP1 antibody, WNCHRS antibody, MT1-MMP antibody, MT-MMP 1 antibody
Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody|Anti-MMP14 antibody [EP1264Y] (ab51074)
SCBT cat No: sc-377097|sc-373908|sc-30074|sc-12367|sc-101451|sc-12366|
| Name | Rabbit polyclonal MMP14 antibody |
|---|---|
| Catalogue No. | A2549 |
| Reactivity | Human, Mouse, Rat |
| Immunogen | Recombinant protein of human MMP14 |
| Host | Rabbit |
| Applications | WB, IHC |
| Recommended dilution | WB 1:500 – 1:2000 |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Molecular weight | Predicted: 65kDa/Observed: Refer to Figures |
| Formulation | MMP14 antibody was tube-contained. |
| Purification | MMP14 antibody was purified using affinity purification. |
| Storage | Store at -20 Celsius degree. Avoid freeze / thaw cycles. |
| Alternative antibody names | MMP-14 antibody, MMP-X1 antibody, MT-MMP antibody, MT1MMP antibody, MTMMP1 antibody, WNCHRS antibody, MT1-MMP antibody, MT-MMP 1 antibody |
| Database links | Human UniProt/Swiss-Prot:P50281 |
| Protein names | MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, MT-MMP 1 |
| Protein function | Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. |
| Protein tissue specificity | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors. |
| Protein sequence and domain | The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.Belongs to the peptidase M10A family.; Contains 4 hemopexin repeats. |
| Protein post-translational modifications | The precursor is cleaved by a furin endopeptidase.; Tyrosine phosphorylated by PKDCC/VLK. |
| Protein cellular localization | Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm. |
| Background | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. |
| Research area | All research areas>Synthesis and Degradation>MT-MMP |
| Note | AntibodyPlus can customize MMP14 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation. |
| Product type | Primary antibody |
| Supplier | ABclonal Inc. |
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