Rabbit polyclonal MMP14 antibody (A2549)

$69.00$259.00

Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Conjugation: Unconjugated
Supplier: ABclonal Inc.

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Rabbit polyclonal MMP14 antibody (A2549)

Supplier: ABclonal Inc.

Recommended applications: WB,IHC

Recommended dilution:

WB 1:500 – 1:2000 IHC 1:50 – 1:100

Recommended protocols: check protocols

Image descriptions:

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Alternative names:

Check alternative names for the antibody

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MMP-14 antibody, MMP-X1 antibody, MT-MMP antibody, MT1MMP antibody, MTMMP1 antibody, WNCHRS antibody, MT1-MMP antibody, MT-MMP 1 antibody
Matrix metallopeptidase 14 (membrane inserted) antibody|Matrix metalloproteinase 14 antibody|Matrix metalloproteinase-14 antibody|Membrane type 1 matrix metalloproteinase antibody|Membrane type 1 metalloprotease antibody|Membrane type matrix metalloproteinase 1 antibody|Membrane-type matrix metalloproteinase 1 antibody|Membrane-type-1 matrix metalloproteinase antibody|MMP 14 antibody|MMP X1 antibody|MMP-14 antibody|MMP-X1 antibody|Mmp14 antibody|MMP14_HUMAN antibody|MMPX1 antibody|MT MMP 1 antibody|MT-MMP 1 antibody|MT1 MMP antibody|MT1-MMP antibody|MT1MMP antibody|MTMMP 1 antibody|MTMMP1 antibody|Anti-MMP14 antibody [EP1264Y] (ab51074)

SCBT cat No: sc-377097|sc-373908|sc-30074|sc-12367|sc-101451|sc-12366|

Name

Rabbit polyclonal MMP14 antibody

Catalogue No.

A2549

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein of human MMP14

Host

Rabbit

Applications

WB, IHC

Recommended dilution

WB 1:500 – 1:2000
IHC 1:50 – 1:100

Clonality

Polyclonal

Conjugation

Unconjugated

Isotype

IgG

Molecular weight

Predicted: 65kDa/Observed: Refer to Figures

Formulation

MMP14 antibody was tube-contained.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purification

MMP14 antibody was purified using affinity purification.

Storage

Store at -20 Celsius degree. Avoid freeze / thaw cycles.

Alternative antibody names

MMP-14 antibody, MMP-X1 antibody, MT-MMP antibody, MT1MMP antibody, MTMMP1 antibody, WNCHRS antibody, MT1-MMP antibody, MT-MMP 1 antibody

Database links

Human UniProt/Swiss-Prot:P50281

Protein names

MMP-14, MMP-X1, MT-MMP, MT1MMP, MTMMP1, WNCHRS, MT1-MMP, MT-MMP 1

Protein function

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

Protein tissue specificity

Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.

Protein sequence and domain

The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.Belongs to the peptidase M10A family.; Contains 4 hemopexin repeats.

Protein post-translational modifications

The precursor is cleaved by a furin endopeptidase.; Tyrosine phosphorylated by PKDCC/VLK.

Protein cellular localization

Membrane ; Single-pass type I membrane protein . Melanosome. Cytoplasm. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm.

Background

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP’s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Research area

All research areas>Synthesis and Degradation>MT-MMP
(View all antibody categories related to Synthesis and Degradation)

Note

AntibodyPlus can customize MMP14 antibody according to your requirement, including bulk product size,etc. Please contact info@antibodyplus.com. AntibodyPlus provides antibody trial sample for your own antibody validation.

Product type

Primary antibody

Supplier

ABclonal Inc.

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